How Influenza Virus Uses Host Cell Pathways during Uncoating
Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. D...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1722 |
| _version_ | 1797527400273149952 |
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| author | Etori Aguiar Moreira Yohei Yamauchi Patrick Matthias |
| author_facet | Etori Aguiar Moreira Yohei Yamauchi Patrick Matthias |
| author_sort | Etori Aguiar Moreira |
| collection | DOAJ |
| description | Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry. |
| first_indexed | 2024-03-10T09:43:20Z |
| format | Article |
| id | doaj.art-a7a82c693655474fb78cc8b13e5f86cb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:20Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a7a82c693655474fb78cc8b13e5f86cb2023-11-22T03:28:59ZengMDPI AGCells2073-44092021-07-01107172210.3390/cells10071722How Influenza Virus Uses Host Cell Pathways during UncoatingEtori Aguiar Moreira0Yohei Yamauchi1Patrick Matthias2Friedrich Miescher Institute for Biomedical Research, 4058 Basel, SwitzerlandFaculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UKFriedrich Miescher Institute for Biomedical Research, 4058 Basel, SwitzerlandInfluenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.https://www.mdpi.com/2073-4409/10/7/1722influenzacapsid uncoatingHDAC6ubiquitinEPS8TNPO1 |
| spellingShingle | Etori Aguiar Moreira Yohei Yamauchi Patrick Matthias How Influenza Virus Uses Host Cell Pathways during Uncoating Cells influenza capsid uncoating HDAC6 ubiquitin EPS8 TNPO1 |
| title | How Influenza Virus Uses Host Cell Pathways during Uncoating |
| title_full | How Influenza Virus Uses Host Cell Pathways during Uncoating |
| title_fullStr | How Influenza Virus Uses Host Cell Pathways during Uncoating |
| title_full_unstemmed | How Influenza Virus Uses Host Cell Pathways during Uncoating |
| title_short | How Influenza Virus Uses Host Cell Pathways during Uncoating |
| title_sort | how influenza virus uses host cell pathways during uncoating |
| topic | influenza capsid uncoating HDAC6 ubiquitin EPS8 TNPO1 |
| url | https://www.mdpi.com/2073-4409/10/7/1722 |
| work_keys_str_mv | AT etoriaguiarmoreira howinfluenzavirususeshostcellpathwaysduringuncoating AT yoheiyamauchi howinfluenzavirususeshostcellpathwaysduringuncoating AT patrickmatthias howinfluenzavirususeshostcellpathwaysduringuncoating |