Hodgkin lymphoma: current conception and unresolved questions
Hodgkin lymphoma is the most frequent lymphoproliferative disorder in the Western world. During one and a half century since it was described by Thomas Hodgkin in 1832 wide experience has been accumulated on matching clinical and morphologic manifestations of disease what is shown in a great number...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2010-01-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2010-04-02/10gvaunp.pdf |
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| author | Gurtovoj V.A. Shponka I.S. Bilenkij I.V. Gritsenko P.O. |
| author_facet | Gurtovoj V.A. Shponka I.S. Bilenkij I.V. Gritsenko P.O. |
| author_sort | Gurtovoj V.A. |
| collection | DOAJ |
| description | Hodgkin lymphoma is the most frequent lymphoproliferative disorder in the Western world. During one and a half century since it was described by Thomas Hodgkin in 1832 wide experience has been accumulated on matching clinical and morphologic manifestations of disease what is shown in a great number of publications. According to World health or-ganization classification of 2008 distinct forms and types of Hodgkin lymphoma were defined in accordance with clinical presentations, pathomorphology and immunophenotype of tumor cells what determine specific treatment. Although clinical manifestations are described well enough, data on morphofunctional features of tumor cells and reactive microenvironment are scarce. Data about the nature of tumor cells are still controversial. Remarkably little attention is paid to the assessment interrelations between morphology, immunophenotype, degree of stability and maturation of diagnostic cells and inflamma-tory background. All these findings may be helpful to clarification of morphogenesis, prognosis and improvement for Hodgkin lymphoma treatment. |
| first_indexed | 2024-12-17T06:09:01Z |
| format | Article |
| id | doaj.art-a7a8c2bf3dc343faa4178a7ca9738bff |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-17T06:09:01Z |
| publishDate | 2010-01-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-a7a8c2bf3dc343faa4178a7ca9738bff2022-12-21T22:00:41ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652010-01-01421321Hodgkin lymphoma: current conception and unresolved questionsGurtovoj V.A.Shponka I.S.Bilenkij I.V.Gritsenko P.O.Hodgkin lymphoma is the most frequent lymphoproliferative disorder in the Western world. During one and a half century since it was described by Thomas Hodgkin in 1832 wide experience has been accumulated on matching clinical and morphologic manifestations of disease what is shown in a great number of publications. According to World health or-ganization classification of 2008 distinct forms and types of Hodgkin lymphoma were defined in accordance with clinical presentations, pathomorphology and immunophenotype of tumor cells what determine specific treatment. Although clinical manifestations are described well enough, data on morphofunctional features of tumor cells and reactive microenvironment are scarce. Data about the nature of tumor cells are still controversial. Remarkably little attention is paid to the assessment interrelations between morphology, immunophenotype, degree of stability and maturation of diagnostic cells and inflamma-tory background. All these findings may be helpful to clarification of morphogenesis, prognosis and improvement for Hodgkin lymphoma treatment.http://www.morphology.dp.ua/_pub/MORPHO-2010-04-02/10gvaunp.pdfHodgkin lymphomaReed-Sternberg cellHodgkin cell |
| spellingShingle | Gurtovoj V.A. Shponka I.S. Bilenkij I.V. Gritsenko P.O. Hodgkin lymphoma: current conception and unresolved questions Морфологія Hodgkin lymphoma Reed-Sternberg cell Hodgkin cell |
| title | Hodgkin lymphoma: current conception and unresolved questions |
| title_full | Hodgkin lymphoma: current conception and unresolved questions |
| title_fullStr | Hodgkin lymphoma: current conception and unresolved questions |
| title_full_unstemmed | Hodgkin lymphoma: current conception and unresolved questions |
| title_short | Hodgkin lymphoma: current conception and unresolved questions |
| title_sort | hodgkin lymphoma current conception and unresolved questions |
| topic | Hodgkin lymphoma Reed-Sternberg cell Hodgkin cell |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2010-04-02/10gvaunp.pdf |
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