Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil
Abstract INTRODUCTION We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious disease referral center. Changes in patient profiles over time were also evaluated. METHODS This retrospective study includ...
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| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2021-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100324&tlng=en |
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| author | Alejandro Marcel Hasslocher-Moreno Roberto Magalhaes Saraiva Pedro Emmanuel Alvarenga Americano do Brasil Luiz Henrique Conde Sangenis Sergio Salles Xavier Andréa Silvestre de Sousa Gilberto Marcelo Sperandio-da-Silva Fernanda de Souza Nogueira Sardinha Mendes Andréa Rodrigues da Costa Marcelo Teixeira de Holanda Henrique Horta Veloso Flavia Mazzoli-Rocha Fernanda Martins Carneiro Luciana Fernandes Portela Mauro Felippe Felix Mediano |
| author_facet | Alejandro Marcel Hasslocher-Moreno Roberto Magalhaes Saraiva Pedro Emmanuel Alvarenga Americano do Brasil Luiz Henrique Conde Sangenis Sergio Salles Xavier Andréa Silvestre de Sousa Gilberto Marcelo Sperandio-da-Silva Fernanda de Souza Nogueira Sardinha Mendes Andréa Rodrigues da Costa Marcelo Teixeira de Holanda Henrique Horta Veloso Flavia Mazzoli-Rocha Fernanda Martins Carneiro Luciana Fernandes Portela Mauro Felippe Felix Mediano |
| author_sort | Alejandro Marcel Hasslocher-Moreno |
| collection | DOAJ |
| description | Abstract INTRODUCTION We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious disease referral center. Changes in patient profiles over time were also evaluated. METHODS This retrospective study included patients with CD from November 1986-December 2019. All patients underwent an evaluation protocol that included sociodemographic profile; epidemiological history; anamnesis; and physical, cardiologic, and digestive examinations. Trend differences for each 5-year period from 1986 to 2019 were tested using a nonparametric trend test for continuous and generalized linear models with binomial distribution for categorical variables. RESULTS A total of 2,168 patients (52.2% women) were included, with a mean age of 47.8 years old. White patients with low levels of education predominated. The reported transmission mode was vectorial in 90.2% of cases. The majority came from areas with a high prevalence (52.2%) and morbidity (67.8%) of CD. The most common clinical presentation was the indeterminate form (44.9%). The number of patients referred gradually decreased and the age at admission increased during the study period, as did the patients’ levels of education. CONCLUSIONS The clinical profile of CD is characterized by a predominance of the indeterminate form of the disease. Regarding the patients who were followed up at the referral center, there was a progressive increase in the mean age and a concomitant decrease in the number of new patients. This reflects the successful control of vector and transfusion transmission in Brazil as well as the aging population of patients with CD. |
| first_indexed | 2024-12-12T09:32:05Z |
| format | Article |
| id | doaj.art-a7abb77f4e834745a1a813e2d5393d42 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T09:32:05Z |
| publishDate | 2021-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-a7abb77f4e834745a1a813e2d5393d422022-12-22T00:28:50ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492021-06-015410.1590/0037-8682-0040-2021Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in BrazilAlejandro Marcel Hasslocher-Morenohttps://orcid.org/0000-0002-5430-7222Roberto Magalhaes Saraivahttps://orcid.org/0000-0002-2263-4261Pedro Emmanuel Alvarenga Americano do Brasilhttps://orcid.org/0000-0002-6700-2268Luiz Henrique Conde Sangenishttps://orcid.org/0000-0002-5948-6282Sergio Salles Xavierhttps://orcid.org/0000-0002-9337-0363Andréa Silvestre de Sousahttps://orcid.org/0000-0001-8266-4801Gilberto Marcelo Sperandio-da-Silvahttps://orcid.org/0000-0002-0468-4417Fernanda de Souza Nogueira Sardinha Mendeshttps://orcid.org/0000-0003-2033-1715Andréa Rodrigues da Costahttps://orcid.org/0000-0002-5033-4856Marcelo Teixeira de Holandahttps://orcid.org/0000-0002-3125-6610Henrique Horta Velosohttps://orcid.org/0000-0002-2743-6555Flavia Mazzoli-Rochahttps://orcid.org/0000-0003-0972-194XFernanda Martins Carneirohttps://orcid.org/0000-0002-3544-9671Luciana Fernandes Portelahttps://orcid.org/0000-0001-8961-468XMauro Felippe Felix Medianohttps://orcid.org/0000-0001-6369-3631Abstract INTRODUCTION We aimed to describe the sociodemographic, epidemiological, and clinical characteristics of patients with chronic Chagas disease (CD) at an infectious disease referral center. Changes in patient profiles over time were also evaluated. METHODS This retrospective study included patients with CD from November 1986-December 2019. All patients underwent an evaluation protocol that included sociodemographic profile; epidemiological history; anamnesis; and physical, cardiologic, and digestive examinations. Trend differences for each 5-year period from 1986 to 2019 were tested using a nonparametric trend test for continuous and generalized linear models with binomial distribution for categorical variables. RESULTS A total of 2,168 patients (52.2% women) were included, with a mean age of 47.8 years old. White patients with low levels of education predominated. The reported transmission mode was vectorial in 90.2% of cases. The majority came from areas with a high prevalence (52.2%) and morbidity (67.8%) of CD. The most common clinical presentation was the indeterminate form (44.9%). The number of patients referred gradually decreased and the age at admission increased during the study period, as did the patients’ levels of education. CONCLUSIONS The clinical profile of CD is characterized by a predominance of the indeterminate form of the disease. Regarding the patients who were followed up at the referral center, there was a progressive increase in the mean age and a concomitant decrease in the number of new patients. This reflects the successful control of vector and transfusion transmission in Brazil as well as the aging population of patients with CD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100324&tlng=enChagas diseaseEpidemiologic studiesCohort studies |
| spellingShingle | Alejandro Marcel Hasslocher-Moreno Roberto Magalhaes Saraiva Pedro Emmanuel Alvarenga Americano do Brasil Luiz Henrique Conde Sangenis Sergio Salles Xavier Andréa Silvestre de Sousa Gilberto Marcelo Sperandio-da-Silva Fernanda de Souza Nogueira Sardinha Mendes Andréa Rodrigues da Costa Marcelo Teixeira de Holanda Henrique Horta Veloso Flavia Mazzoli-Rocha Fernanda Martins Carneiro Luciana Fernandes Portela Mauro Felippe Felix Mediano Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Epidemiologic studies Cohort studies |
| title | Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil |
| title_full | Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil |
| title_fullStr | Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil |
| title_full_unstemmed | Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil |
| title_short | Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil |
| title_sort | temporal changes in the clinical epidemiological profile of patients with chagas disease at a referral center in brazil |
| topic | Chagas disease Epidemiologic studies Cohort studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100324&tlng=en |
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