Can EDTA Change MRSA into MSSA? A Future Prospective!
Introduction: In the present era we are left behind with limited options for the treatment of serious infections caused by multidrug resistant S.aureus, most remarkably nosocomially acquired Methicillin resistant S.aureus (MRSA). The problem increases more when these strains easily become multid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7280/17944_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(AGAK).pdf |
| Summary: | Introduction: In the present era we are left behind with limited
options for the treatment of serious infections caused by
multidrug resistant S.aureus, most remarkably nosocomially
acquired Methicillin resistant S.aureus (MRSA). The problem
increases more when these strains easily become multidrug
resistant (MDR) due to biofilm formation. Those staphylococcal
species that are vancomycin and linezolid resistant are also
resistant to other antistaphylococcal agents which call for an
urgent intervention to develop newer antimicrobial agents.
Aim: The present study was undertaken with the aim to evaluate
the antibiofilm effect of EDTA against the biofilm forming MRSA
isolates, isolated from different clinical infections.
Materials and Methods: The biofilms formed on polystyrene
microtitre plates by the MRSA strains were treated by different
concentrations of EDTA to find out its anti-biofilm activity.
Further simultaneously the antibiotic susceptibility pattern was
noted down to check whether the MRSA strains become MSSA
(Methicillin sensitive S.aureus).
Results: Our data demonstrates that EDTA at 4mM concentration
inhibits biofilm of MRSA and at 20 mM have an ability to reduce
and dissociate the biofilm membrane, allowing the antibiotics to
enter and convert MRSA strains into MSSA.
Conclusion: These findings suggest that commercially available
EDTA could be used in future to control MRSA and its biofilmrelated infections. |
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| ISSN: | 2249-782X 0973-709X |