Integration of <i>Salmonella</i> into Combination Cancer Therapy
Current modalities of cancer treatment have limitations related to poor target selectivity, resistance to treatment, and low response rates in patients. Accumulating evidence over the past few decades has demonstrated the capacity of several strains of bacteria to exert anti-tumor activities. <i&...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/13/3228 |
| _version_ | 1797411578826457088 |
|---|---|
| author | Besan H. Al-Saafeen Maria J. Fernandez-Cabezudo Basel K. al-Ramadi |
| author_facet | Besan H. Al-Saafeen Maria J. Fernandez-Cabezudo Basel K. al-Ramadi |
| author_sort | Besan H. Al-Saafeen |
| collection | DOAJ |
| description | Current modalities of cancer treatment have limitations related to poor target selectivity, resistance to treatment, and low response rates in patients. Accumulating evidence over the past few decades has demonstrated the capacity of several strains of bacteria to exert anti-tumor activities. <i>Salmonella</i> is the most extensively studied entity in bacterial-mediated cancer therapy, and has a good potential to induce direct tumor cell killing and manipulate the immune components of the tumor microenvironment in favor of tumor inhibition. In addition, <i>Salmonella</i> possesses some advantages over other approaches of cancer therapy, including high tumor specificity, deep tissue penetration, and engineering plasticity. These aspects underscore the potential of utilizing <i>Salmonella</i> in combination with other cancer therapeutics to improve treatment effectiveness. Herein, we describe the advantages that make <i>Salmonella</i> a good candidate for combination cancer therapy and summarize the findings of representative studies that aimed to investigate the therapeutic outcome of combination therapies involving <i>Salmonella</i>. We also highlight issues associated with their application in clinical use. |
| first_indexed | 2024-03-09T04:47:08Z |
| format | Article |
| id | doaj.art-a7ac2ad1fc7c4b689b637aa957fcf1a0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:47:08Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a7ac2ad1fc7c4b689b637aa957fcf1a02023-12-03T13:14:06ZengMDPI AGCancers2072-66942021-06-011313322810.3390/cancers13133228Integration of <i>Salmonella</i> into Combination Cancer TherapyBesan H. Al-Saafeen0Maria J. Fernandez-Cabezudo1Basel K. al-Ramadi2Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab EmiratesDepartment of Biochemistry and Molecular Biology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab EmiratesDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab EmiratesCurrent modalities of cancer treatment have limitations related to poor target selectivity, resistance to treatment, and low response rates in patients. Accumulating evidence over the past few decades has demonstrated the capacity of several strains of bacteria to exert anti-tumor activities. <i>Salmonella</i> is the most extensively studied entity in bacterial-mediated cancer therapy, and has a good potential to induce direct tumor cell killing and manipulate the immune components of the tumor microenvironment in favor of tumor inhibition. In addition, <i>Salmonella</i> possesses some advantages over other approaches of cancer therapy, including high tumor specificity, deep tissue penetration, and engineering plasticity. These aspects underscore the potential of utilizing <i>Salmonella</i> in combination with other cancer therapeutics to improve treatment effectiveness. Herein, we describe the advantages that make <i>Salmonella</i> a good candidate for combination cancer therapy and summarize the findings of representative studies that aimed to investigate the therapeutic outcome of combination therapies involving <i>Salmonella</i>. We also highlight issues associated with their application in clinical use.https://www.mdpi.com/2072-6694/13/13/3228<i>Salmonella</i>cancercombination therapyimmunotherapy |
| spellingShingle | Besan H. Al-Saafeen Maria J. Fernandez-Cabezudo Basel K. al-Ramadi Integration of <i>Salmonella</i> into Combination Cancer Therapy Cancers <i>Salmonella</i> cancer combination therapy immunotherapy |
| title | Integration of <i>Salmonella</i> into Combination Cancer Therapy |
| title_full | Integration of <i>Salmonella</i> into Combination Cancer Therapy |
| title_fullStr | Integration of <i>Salmonella</i> into Combination Cancer Therapy |
| title_full_unstemmed | Integration of <i>Salmonella</i> into Combination Cancer Therapy |
| title_short | Integration of <i>Salmonella</i> into Combination Cancer Therapy |
| title_sort | integration of i salmonella i into combination cancer therapy |
| topic | <i>Salmonella</i> cancer combination therapy immunotherapy |
| url | https://www.mdpi.com/2072-6694/13/13/3228 |
| work_keys_str_mv | AT besanhalsaafeen integrationofisalmonellaiintocombinationcancertherapy AT mariajfernandezcabezudo integrationofisalmonellaiintocombinationcancertherapy AT baselkalramadi integrationofisalmonellaiintocombinationcancertherapy |