Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005.
The detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3861328?pdf=render |
| _version_ | 1828318580160069632 |
|---|---|
| author | Ann E Wiringa Kathleen A Shutt Jane W Marsh Amanda C Cohn Nancy E Messonnier Shelley M Zansky Susan Petit Monica M Farley Ken Gershman Ruth Lynfield Arthur Reingold William Schaffner Jamie Thompson Shawn T Brown Bruce Y Lee Lee H Harrison |
| author_facet | Ann E Wiringa Kathleen A Shutt Jane W Marsh Amanda C Cohn Nancy E Messonnier Shelley M Zansky Susan Petit Monica M Farley Ken Gershman Ruth Lynfield Arthur Reingold William Schaffner Jamie Thompson Shawn T Brown Bruce Y Lee Lee H Harrison |
| author_sort | Ann E Wiringa |
| collection | DOAJ |
| description | The detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in the United States are believed to be sporadic.Meningococcal isolates from 9 Active Bacterial Core surveillance sites throughout the United States from 2000 through 2005 were classified according to serogroup, multilocus sequence typing, and outer membrane protein (porA, porB, and fetA) genotyping. Clones were defined as isolates that were indistinguishable according to this characterization. Case data were aggregated to the census tract level and all non-singleton clones were assessed for non-random spatial and temporal clustering using retrospective space-time analyses with a discrete Poisson probability model.Among 1,062 geocoded cases with available isolates, 438 unique clones were identified, 78 of which had ≥2 isolates. 702 cases were attributable to non-singleton clones, accounting for 66.0% of all geocoded cases. 32 statistically significant clusters comprised of 107 cases (10.1% of all geocoded cases) were identified. Clusters had the following attributes: included 2 to 11 cases; 1 day to 33 months duration; radius of 0 to 61.7 km; and attack rate of 0.7 to 57.8 cases per 100,000 population. Serogroups represented among the clusters were: B (n = 12 clusters, 45 cases), C (n = 11 clusters, 27 cases), and Y (n = 9 clusters, 35 cases); 20 clusters (62.5%) were caused by serogroups represented in meningococcal vaccines that are commercially available in the United States.Around 10% of meningococcal disease cases in the U.S. could be assigned to a geotemporal cluster. Molecular characterization of isolates, combined with geotemporal analysis, is a useful tool for understanding the spread of virulent meningococcal clones and patterns of transmission in populations. |
| first_indexed | 2024-04-13T17:45:23Z |
| format | Article |
| id | doaj.art-a7acbf00ba444a03aae25ce51801ace5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T17:45:23Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a7acbf00ba444a03aae25ce51801ace52022-12-22T02:37:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8204810.1371/journal.pone.0082048Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005.Ann E WiringaKathleen A ShuttJane W MarshAmanda C CohnNancy E MessonnierShelley M ZanskySusan PetitMonica M FarleyKen GershmanRuth LynfieldArthur ReingoldWilliam SchaffnerJamie ThompsonShawn T BrownBruce Y LeeLee H HarrisonThe detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in the United States are believed to be sporadic.Meningococcal isolates from 9 Active Bacterial Core surveillance sites throughout the United States from 2000 through 2005 were classified according to serogroup, multilocus sequence typing, and outer membrane protein (porA, porB, and fetA) genotyping. Clones were defined as isolates that were indistinguishable according to this characterization. Case data were aggregated to the census tract level and all non-singleton clones were assessed for non-random spatial and temporal clustering using retrospective space-time analyses with a discrete Poisson probability model.Among 1,062 geocoded cases with available isolates, 438 unique clones were identified, 78 of which had ≥2 isolates. 702 cases were attributable to non-singleton clones, accounting for 66.0% of all geocoded cases. 32 statistically significant clusters comprised of 107 cases (10.1% of all geocoded cases) were identified. Clusters had the following attributes: included 2 to 11 cases; 1 day to 33 months duration; radius of 0 to 61.7 km; and attack rate of 0.7 to 57.8 cases per 100,000 population. Serogroups represented among the clusters were: B (n = 12 clusters, 45 cases), C (n = 11 clusters, 27 cases), and Y (n = 9 clusters, 35 cases); 20 clusters (62.5%) were caused by serogroups represented in meningococcal vaccines that are commercially available in the United States.Around 10% of meningococcal disease cases in the U.S. could be assigned to a geotemporal cluster. Molecular characterization of isolates, combined with geotemporal analysis, is a useful tool for understanding the spread of virulent meningococcal clones and patterns of transmission in populations.http://europepmc.org/articles/PMC3861328?pdf=render |
| spellingShingle | Ann E Wiringa Kathleen A Shutt Jane W Marsh Amanda C Cohn Nancy E Messonnier Shelley M Zansky Susan Petit Monica M Farley Ken Gershman Ruth Lynfield Arthur Reingold William Schaffner Jamie Thompson Shawn T Brown Bruce Y Lee Lee H Harrison Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. PLoS ONE |
| title | Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. |
| title_full | Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. |
| title_fullStr | Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. |
| title_full_unstemmed | Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. |
| title_short | Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005. |
| title_sort | geotemporal analysis of neisseria meningitidis clones in the united states 2000 2005 |
| url | http://europepmc.org/articles/PMC3861328?pdf=render |
| work_keys_str_mv | AT annewiringa geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT kathleenashutt geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT janewmarsh geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT amandaccohn geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT nancyemessonnier geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT shelleymzansky geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT susanpetit geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT monicamfarley geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT kengershman geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT ruthlynfield geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT arthurreingold geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT williamschaffner geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT jamiethompson geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT shawntbrown geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT bruceylee geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 AT leehharrison geotemporalanalysisofneisseriameningitidisclonesintheunitedstates20002005 |