Rivaroxaban Suppresses Atherosclerosis by Inhibiting FXa-Induced Macrophage M1 Polarization-Mediated Phenotypic Conversion of Vascular Smooth Muscle Cells

Rivaroxaban Suppresses Atherosclerosis by Inhibiting FXa-Induced Macrophage M1 Polarization-Mediated Phenotypic Conversion of Vascular Smooth Muscle Cells

Background: Factor Xa (FXa) is a mediator initiating and accelerating atherosclerosis (AS). Both macrophage and vascular smooth muscle cells (VSMCs) participate in AS progression. This study was aimed to investigate the mechanisms underlying the effects of the FXa inhibitor rivaroxaban on AS.Methods...

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Bibliographic Details
Main Authors: Yanpeng Ma, Yong Zhang, Chuan Qiu, Chunhui He, Ting He, Shuang Shi, Zhongwei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
atherosclerosis
macrophage
vascular smooth muscle cell
polarization
phenotypic conversion
factor Xa
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.739212/full

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