Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy
The glomerular filtration barrier, comprising the inner layer of capillary fenestrated endothelial cells, outermost podocytes, and the glomerular basement membrane between them, plays a pivotal role in kidney function. Podocytes, terminally differentiated epithelial cells, are challenging to regener...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335936/full |
| _version_ | 1797355231692980224 |
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| author | Hong Jiang Zhirang Shen Jing Zhuang Chen Lu Yue Qu Chengren Xu Shufen Yang Xuefei Tian |
| author_facet | Hong Jiang Zhirang Shen Jing Zhuang Chen Lu Yue Qu Chengren Xu Shufen Yang Xuefei Tian |
| author_sort | Hong Jiang |
| collection | DOAJ |
| description | The glomerular filtration barrier, comprising the inner layer of capillary fenestrated endothelial cells, outermost podocytes, and the glomerular basement membrane between them, plays a pivotal role in kidney function. Podocytes, terminally differentiated epithelial cells, are challenging to regenerate once injured. They are essential for maintaining the integrity of the glomerular filtration barrier. Damage to podocytes, resulting from intrinsic or extrinsic factors, leads to proteinuria in the early stages and eventually progresses to chronic kidney disease (CKD). Immune-mediated podocyte injury is a primary pathogenic mechanism in proteinuric glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and lupus nephritis with podocyte involvement. An extensive body of evidence indicates that podocytes not only contribute significantly to the maintenance of the glomerular filtration barrier and serve as targets of immune responses but also exhibit immune cell-like characteristics, participating in both innate and adaptive immunity. They play a pivotal role in mediating glomerular injury and represent potential therapeutic targets for CKD. This review aims to systematically elucidate the mechanisms of podocyte immune injury in various podocyte lesions and provide an overview of recent advances in podocyte immunotherapy. It offers valuable insights for a deeper understanding of the role of podocytes in proteinuric glomerular diseases, and the identification of new therapeutic targets, and has significant implications for the future clinical diagnosis and treatment of podocyte-related disorders. |
| first_indexed | 2024-03-08T14:08:17Z |
| format | Article |
| id | doaj.art-a7aec73e6a974a198730036d15bcd80a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T14:08:17Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a7aec73e6a974a198730036d15bcd80a2024-01-15T04:24:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13359361335936Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapyHong Jiang0Zhirang Shen1Jing Zhuang2Chen Lu3Yue Qu4Chengren Xu5Shufen Yang6Xuefei Tian7Division of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDivision of Nephrology, Department of Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United StatesThe glomerular filtration barrier, comprising the inner layer of capillary fenestrated endothelial cells, outermost podocytes, and the glomerular basement membrane between them, plays a pivotal role in kidney function. Podocytes, terminally differentiated epithelial cells, are challenging to regenerate once injured. They are essential for maintaining the integrity of the glomerular filtration barrier. Damage to podocytes, resulting from intrinsic or extrinsic factors, leads to proteinuria in the early stages and eventually progresses to chronic kidney disease (CKD). Immune-mediated podocyte injury is a primary pathogenic mechanism in proteinuric glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and lupus nephritis with podocyte involvement. An extensive body of evidence indicates that podocytes not only contribute significantly to the maintenance of the glomerular filtration barrier and serve as targets of immune responses but also exhibit immune cell-like characteristics, participating in both innate and adaptive immunity. They play a pivotal role in mediating glomerular injury and represent potential therapeutic targets for CKD. This review aims to systematically elucidate the mechanisms of podocyte immune injury in various podocyte lesions and provide an overview of recent advances in podocyte immunotherapy. It offers valuable insights for a deeper understanding of the role of podocytes in proteinuric glomerular diseases, and the identification of new therapeutic targets, and has significant implications for the future clinical diagnosis and treatment of podocyte-related disorders.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335936/fullpodocyteimmunity responsepathogenesisproteinuriatreatment |
| spellingShingle | Hong Jiang Zhirang Shen Jing Zhuang Chen Lu Yue Qu Chengren Xu Shufen Yang Xuefei Tian Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy Frontiers in Immunology podocyte immunity response pathogenesis proteinuria treatment |
| title | Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy |
| title_full | Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy |
| title_fullStr | Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy |
| title_full_unstemmed | Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy |
| title_short | Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy |
| title_sort | understanding the podocyte immune responses in proteinuric kidney diseases from pathogenesis to therapy |
| topic | podocyte immunity response pathogenesis proteinuria treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335936/full |
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