Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity
Higher body weight is known to negatively impact plasma vitamin C status. However, despite this well-documented inverse association, recommendations on daily vitamin C intakes by health authorities worldwide do not include particular reference values for people of higher body weight. This suggests t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1460 |
| _version_ | 1797438133086715904 |
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| author | Anitra C. Carr Gladys Block Jens Lykkesfeldt |
| author_facet | Anitra C. Carr Gladys Block Jens Lykkesfeldt |
| author_sort | Anitra C. Carr |
| collection | DOAJ |
| description | Higher body weight is known to negatively impact plasma vitamin C status. However, despite this well-documented inverse association, recommendations on daily vitamin C intakes by health authorities worldwide do not include particular reference values for people of higher body weight. This suggests that people of higher body weight and people with obesity may be receiving insufficient vitamin C in spite of ingesting the amounts recommended by their health authorities. The current preliminary investigation sought to estimate how much additional vitamin C people with higher body weights would need to consume in order to attain a comparable vitamin C status to that of a lower weight person consuming an average Western vitamin C intake. Data from two published vitamin C dose-concentration studies were used to generate the relationship: a detailed pharmacokinetic study with seven healthy non-smoking men and a multiple depletion–repletion study with 68 healthy non-smoking men of varying body weights. Our estimates suggest that an additional intake of 10 mg vitamin C/day is required for every 10 kg increase in body weight to attain a comparable plasma concentration to a 60 kg individual with a vitamin C intake of ~110 mg/day, which is the daily intake recommended by the European Food Safety Authority (EFSA). Thus, individuals weighing e.g., 80 and 90 kg will need to consume ~130 and 140 mg vitamin C/day, respectively. People with obesity will likely need even higher vitamin C intakes. As poor vitamin C status is associated with increased risk of several chronic diseases including cardiovascular disease, these findings may have important public health implications. As such, dose-finding studies are required to determine optimal vitamin C intakes for overweight and obese people. |
| first_indexed | 2024-03-09T11:32:50Z |
| format | Article |
| id | doaj.art-a7b0858e5917430eb88b8cff8a8e8124 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:50Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a7b0858e5917430eb88b8cff8a8e81242023-11-30T23:48:33ZengMDPI AGNutrients2072-66432022-03-01147146010.3390/nu14071460Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for ObesityAnitra C. Carr0Gladys Block1Jens Lykkesfeldt2Nutrition in Medicine Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch 8011, New ZealandSchool of Public Health, University of California, Berkeley, Berkeley, CA 94720-7360, USAFaculty of Health & Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg C, DenmarkHigher body weight is known to negatively impact plasma vitamin C status. However, despite this well-documented inverse association, recommendations on daily vitamin C intakes by health authorities worldwide do not include particular reference values for people of higher body weight. This suggests that people of higher body weight and people with obesity may be receiving insufficient vitamin C in spite of ingesting the amounts recommended by their health authorities. The current preliminary investigation sought to estimate how much additional vitamin C people with higher body weights would need to consume in order to attain a comparable vitamin C status to that of a lower weight person consuming an average Western vitamin C intake. Data from two published vitamin C dose-concentration studies were used to generate the relationship: a detailed pharmacokinetic study with seven healthy non-smoking men and a multiple depletion–repletion study with 68 healthy non-smoking men of varying body weights. Our estimates suggest that an additional intake of 10 mg vitamin C/day is required for every 10 kg increase in body weight to attain a comparable plasma concentration to a 60 kg individual with a vitamin C intake of ~110 mg/day, which is the daily intake recommended by the European Food Safety Authority (EFSA). Thus, individuals weighing e.g., 80 and 90 kg will need to consume ~130 and 140 mg vitamin C/day, respectively. People with obesity will likely need even higher vitamin C intakes. As poor vitamin C status is associated with increased risk of several chronic diseases including cardiovascular disease, these findings may have important public health implications. As such, dose-finding studies are required to determine optimal vitamin C intakes for overweight and obese people.https://www.mdpi.com/2072-6643/14/7/1460vitamin Cascorbateobesitybody weightvitamin C intakeplasma ascorbate concentrations |
| spellingShingle | Anitra C. Carr Gladys Block Jens Lykkesfeldt Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity Nutrients vitamin C ascorbate obesity body weight vitamin C intake plasma ascorbate concentrations |
| title | Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity |
| title_full | Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity |
| title_fullStr | Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity |
| title_full_unstemmed | Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity |
| title_short | Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity |
| title_sort | estimation of vitamin c intake requirements based on body weight implications for obesity |
| topic | vitamin C ascorbate obesity body weight vitamin C intake plasma ascorbate concentrations |
| url | https://www.mdpi.com/2072-6643/14/7/1460 |
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