Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report
Introduction . Epidermal growth factor receptor inhibitors (EGFRI) are commonly used in the treatment of solid tumors. Cutaneous side effects occur in 80% of patients and are the most frequent adverse events. However, cicatricial alopecia is a rarely described side effect of EGFRI. Objective . To...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-10-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Severe-cicatricial-alopecia-as-a-rare-cutaneous-side-effect-due-to-erlotinib-case-report,56,28518,1,1.html |
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| author | Magdalena Żychowska Aleksandra Batycka-Baran Wojciech Baran Joanna Maj |
| author_facet | Magdalena Żychowska Aleksandra Batycka-Baran Wojciech Baran Joanna Maj |
| author_sort | Magdalena Żychowska |
| collection | DOAJ |
| description | Introduction . Epidermal growth factor receptor inhibitors (EGFRI) are commonly used in the treatment of solid tumors. Cutaneous side effects occur in 80% of patients and are the most frequent adverse events. However, cicatricial alopecia is a rarely described side effect of EGFRI.
Objective . To present cutaneous toxicities in a patient treated with erlotinib and underscore cicatricial alopecia, rarely described in the literature.
Case report. We present a 63-year-old woman diagnosed with non-small cell lung cancer and treated with erlotinib, who developed extensive papulo-pustular eruption with severe involvement of the scalp and cicatricial alopecia. Other adverse events included trichomegaly, paronychia, granuloma pyogenicum-like lesions, dryness of the skin and pruritus.
Conclusions . Cicatricial alopecia in the presented patient may be a result of delayed introduction of dermatological treatment. Therefore, all dermatologists should be aware of treatment modalities of EGFRI-induced toxicities. |
| first_indexed | 2024-04-13T00:00:38Z |
| format | Article |
| id | doaj.art-a7b0a9ebd99c4bacbae3583a122afae3 |
| institution | Directory Open Access Journal |
| issn | 0033-2526 2084-9893 |
| language | English |
| last_indexed | 2024-04-13T00:00:38Z |
| publishDate | 2016-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Przegląd Dermatologiczny |
| spelling | doaj.art-a7b0a9ebd99c4bacbae3583a122afae32022-12-22T03:11:23ZengTermedia Publishing HousePrzegląd Dermatologiczny0033-25262084-98932016-10-01103537137510.5114/dr.2016.6288828518Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case reportMagdalena ŻychowskaAleksandra Batycka-BaranWojciech BaranJoanna MajIntroduction . Epidermal growth factor receptor inhibitors (EGFRI) are commonly used in the treatment of solid tumors. Cutaneous side effects occur in 80% of patients and are the most frequent adverse events. However, cicatricial alopecia is a rarely described side effect of EGFRI. Objective . To present cutaneous toxicities in a patient treated with erlotinib and underscore cicatricial alopecia, rarely described in the literature. Case report. We present a 63-year-old woman diagnosed with non-small cell lung cancer and treated with erlotinib, who developed extensive papulo-pustular eruption with severe involvement of the scalp and cicatricial alopecia. Other adverse events included trichomegaly, paronychia, granuloma pyogenicum-like lesions, dryness of the skin and pruritus. Conclusions . Cicatricial alopecia in the presented patient may be a result of delayed introduction of dermatological treatment. Therefore, all dermatologists should be aware of treatment modalities of EGFRI-induced toxicities.https://www.termedia.pl/Severe-cicatricial-alopecia-as-a-rare-cutaneous-side-effect-due-to-erlotinib-case-report,56,28518,1,1.htmlerlotinib alopecia cicatricial alopecia epidermal growth factor receptor inhibitors |
| spellingShingle | Magdalena Żychowska Aleksandra Batycka-Baran Wojciech Baran Joanna Maj Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report Przegląd Dermatologiczny erlotinib alopecia cicatricial alopecia epidermal growth factor receptor inhibitors |
| title | Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report |
| title_full | Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report |
| title_fullStr | Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report |
| title_full_unstemmed | Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report |
| title_short | Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report |
| title_sort | severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib case report |
| topic | erlotinib alopecia cicatricial alopecia epidermal growth factor receptor inhibitors |
| url | https://www.termedia.pl/Severe-cicatricial-alopecia-as-a-rare-cutaneous-side-effect-due-to-erlotinib-case-report,56,28518,1,1.html |
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