Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis

Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis

We have previously identified a human CD8+HLA-DR+ regulatory T cell subset with the ability to suppress proliferation of autologous PBMCs responder cells through cell contact and CTLA-4 co-inhibitory molecule. The present study characterizes the complete phenotype of CD8+HLA-DR+ Treg cells which sho...

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Bibliographic Details
Main Authors: Andres Machicote, Santiago Belén, Placida Baz, Luis A. Billordo, Leonardo Fainboim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
CD8+HLA-DR+
PD-1/PD-L1
TIGIT
CCR4
CD127
regulatory T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02788/full

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