Scaffolds for Dentin–Pulp Complex Regeneration
<i>Background and Objectives</i>: Regenerative dentistry aims to regenerate the pulp–dentin complex and restore those of its functions that have become compromised by pulp injury and/or inflammation. Scaffold-based techniques are a regeneration strategy that replicate a biological enviro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/1/7 |
| _version_ | 1797343011707813888 |
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| author | Diana B. Sequeira Patrícia Diogo Brenda P. F. A. Gomes João Peça João Miguel Marques Santos |
| author_facet | Diana B. Sequeira Patrícia Diogo Brenda P. F. A. Gomes João Peça João Miguel Marques Santos |
| author_sort | Diana B. Sequeira |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Regenerative dentistry aims to regenerate the pulp–dentin complex and restore those of its functions that have become compromised by pulp injury and/or inflammation. Scaffold-based techniques are a regeneration strategy that replicate a biological environment by utilizing a suitable scaffold, which is considered crucial for the successful regeneration of dental pulp. The aim of the present review is to address the main characteristics of the different scaffolds, as well as their application in dentin–pulp complex regeneration. <i>Materials and Methods</i>: A narrative review was conducted by two independent reviewers to answer the research question: What type of scaffolds can be used in dentin–pulp complex regeneration? An electronic search of PubMed, EMBASE and Cochrane library databases was undertaken. Keywords including “pulp-dentin regeneration scaffold” and “pulp-dentin complex regeneration” were used. To locate additional reports, reference mining of the identified papers was undertaken. <i>Results</i>: A wide variety of biomaterials is already available for tissue engineering and can be broadly categorized into two groups: (i) natural, and (ii) synthetic, scaffolds. Natural scaffolds often contain bioactive molecules, growth factors, and signaling cues that can positively influence cell behavior. These signaling molecules can promote specific cellular responses, such as cell proliferation and differentiation, crucial for effective tissue regeneration. Synthetic scaffolds offer flexibility in design and can be tailored to meet specific requirements, such as size, shape, and mechanical properties. Moreover, they can be functionalized with bioactive molecules, growth factors, or signaling cues to enhance their biological properties and the manufacturing process can be standardized, ensuring consistent quality for widespread clinical use. <i>Conclusions</i>: There is still a lack of evidence to determine the optimal scaffold composition that meets the specific requirements and complexities needed for effectively promoting dental pulp tissue engineering and achieving successful clinical outcomes. |
| first_indexed | 2024-03-08T10:41:30Z |
| format | Article |
| id | doaj.art-a7b5095d85f94b83951fba6dc840c386 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:30Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a7b5095d85f94b83951fba6dc840c3862024-01-26T17:34:40ZengMDPI AGMedicina1010-660X1648-91442023-12-01601710.3390/medicina60010007Scaffolds for Dentin–Pulp Complex RegenerationDiana B. Sequeira0Patrícia Diogo1Brenda P. F. A. Gomes2João Peça3João Miguel Marques Santos4Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, PortugalInstitute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, PortugalDepartment of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas—UNICAMP, Piracicaba 13083-970, BrazilCenter for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalInstitute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal<i>Background and Objectives</i>: Regenerative dentistry aims to regenerate the pulp–dentin complex and restore those of its functions that have become compromised by pulp injury and/or inflammation. Scaffold-based techniques are a regeneration strategy that replicate a biological environment by utilizing a suitable scaffold, which is considered crucial for the successful regeneration of dental pulp. The aim of the present review is to address the main characteristics of the different scaffolds, as well as their application in dentin–pulp complex regeneration. <i>Materials and Methods</i>: A narrative review was conducted by two independent reviewers to answer the research question: What type of scaffolds can be used in dentin–pulp complex regeneration? An electronic search of PubMed, EMBASE and Cochrane library databases was undertaken. Keywords including “pulp-dentin regeneration scaffold” and “pulp-dentin complex regeneration” were used. To locate additional reports, reference mining of the identified papers was undertaken. <i>Results</i>: A wide variety of biomaterials is already available for tissue engineering and can be broadly categorized into two groups: (i) natural, and (ii) synthetic, scaffolds. Natural scaffolds often contain bioactive molecules, growth factors, and signaling cues that can positively influence cell behavior. These signaling molecules can promote specific cellular responses, such as cell proliferation and differentiation, crucial for effective tissue regeneration. Synthetic scaffolds offer flexibility in design and can be tailored to meet specific requirements, such as size, shape, and mechanical properties. Moreover, they can be functionalized with bioactive molecules, growth factors, or signaling cues to enhance their biological properties and the manufacturing process can be standardized, ensuring consistent quality for widespread clinical use. <i>Conclusions</i>: There is still a lack of evidence to determine the optimal scaffold composition that meets the specific requirements and complexities needed for effectively promoting dental pulp tissue engineering and achieving successful clinical outcomes.https://www.mdpi.com/1648-9144/60/1/7dental pulpguided tissue regenerationtissue scaffoldsbiocompatible materials |
| spellingShingle | Diana B. Sequeira Patrícia Diogo Brenda P. F. A. Gomes João Peça João Miguel Marques Santos Scaffolds for Dentin–Pulp Complex Regeneration Medicina dental pulp guided tissue regeneration tissue scaffolds biocompatible materials |
| title | Scaffolds for Dentin–Pulp Complex Regeneration |
| title_full | Scaffolds for Dentin–Pulp Complex Regeneration |
| title_fullStr | Scaffolds for Dentin–Pulp Complex Regeneration |
| title_full_unstemmed | Scaffolds for Dentin–Pulp Complex Regeneration |
| title_short | Scaffolds for Dentin–Pulp Complex Regeneration |
| title_sort | scaffolds for dentin pulp complex regeneration |
| topic | dental pulp guided tissue regeneration tissue scaffolds biocompatible materials |
| url | https://www.mdpi.com/1648-9144/60/1/7 |
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