Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses
Some insoluble aluminum salts are commonly used in injectable vaccines as adjuvants to accelerate, prolong, or enhance the antigen-specific immune responses. Data from previous studies testing the nasal mucosal vaccine adjuvant activity of aluminum salts are conflicting. The present study is designe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1365995 |
| _version_ | 1797677564965158912 |
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| author | Haiyue Xu Tinashe B. Ruwona Sachin G. Thakkar Yanping Chen Mingtao Zeng Zhengrong Cui |
| author_facet | Haiyue Xu Tinashe B. Ruwona Sachin G. Thakkar Yanping Chen Mingtao Zeng Zhengrong Cui |
| author_sort | Haiyue Xu |
| collection | DOAJ |
| description | Some insoluble aluminum salts are commonly used in injectable vaccines as adjuvants to accelerate, prolong, or enhance the antigen-specific immune responses. Data from previous studies testing the nasal mucosal vaccine adjuvant activity of aluminum salts are conflicting. The present study is designed to further assess the feasibility of using aluminum salts in injectable vaccines as nasal mucosal vaccine adjuvants. Using Alhydrogel®, the international scientific standard of aluminum (oxy)hydroxide gels, and ovalbumin or 3 × M2e-HA2, a synthetic influenza virus fusion protein, as antigens, we showed in a mouse model that when dosed intranasally Alhydrogel® enables antigens adsorbed on it to induce stronger antigen-specific immune responses in both serum samples (e.g., specific IgG) and nasal and lung mucosal secretions (i.e., specific IgA) in all immunized mice, as compared with nasal immunization with the antigens alone. Rerouting insoluble aluminum salts in injectable vaccines may represent a viable approach for (nasal) mucosal vaccine adjuvant discovery. |
| first_indexed | 2024-03-11T22:47:07Z |
| format | Article |
| id | doaj.art-a7b5d4083a41497ea32d1d8ddac25820 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:07Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-a7b5d4083a41497ea32d1d8ddac258202023-09-22T08:17:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-11-0113112688269410.1080/21645515.2017.13659951365995Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responsesHaiyue Xu0Tinashe B. Ruwona1Sachin G. Thakkar2Yanping Chen3Mingtao Zeng4Zhengrong Cui5The University of Texas at Austin, College of PharmacyThe University of Texas at Austin, College of PharmacyThe University of Texas at Austin, College of PharmacyTexas Tech University Health Sciences Center El PasoTexas Tech University Health Sciences Center El PasoThe University of Texas at Austin, College of PharmacySome insoluble aluminum salts are commonly used in injectable vaccines as adjuvants to accelerate, prolong, or enhance the antigen-specific immune responses. Data from previous studies testing the nasal mucosal vaccine adjuvant activity of aluminum salts are conflicting. The present study is designed to further assess the feasibility of using aluminum salts in injectable vaccines as nasal mucosal vaccine adjuvants. Using Alhydrogel®, the international scientific standard of aluminum (oxy)hydroxide gels, and ovalbumin or 3 × M2e-HA2, a synthetic influenza virus fusion protein, as antigens, we showed in a mouse model that when dosed intranasally Alhydrogel® enables antigens adsorbed on it to induce stronger antigen-specific immune responses in both serum samples (e.g., specific IgG) and nasal and lung mucosal secretions (i.e., specific IgA) in all immunized mice, as compared with nasal immunization with the antigens alone. Rerouting insoluble aluminum salts in injectable vaccines may represent a viable approach for (nasal) mucosal vaccine adjuvant discovery.http://dx.doi.org/10.1080/21645515.2017.1365995aluminum saltsantibody responsescytokine releasemplamucosal vaccine adjuvant |
| spellingShingle | Haiyue Xu Tinashe B. Ruwona Sachin G. Thakkar Yanping Chen Mingtao Zeng Zhengrong Cui Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses Human Vaccines & Immunotherapeutics aluminum salts antibody responses cytokine release mpla mucosal vaccine adjuvant |
| title | Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| title_full | Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| title_fullStr | Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| title_full_unstemmed | Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| title_short | Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| title_sort | nasal aluminum oxy hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses |
| topic | aluminum salts antibody responses cytokine release mpla mucosal vaccine adjuvant |
| url | http://dx.doi.org/10.1080/21645515.2017.1365995 |
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