Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok
Cigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreat...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2010-12-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/36 |
| _version_ | 1828973039188967424 |
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| author | Santun Bhekti Rahimah Herri S. Sastramihardja Trully Detty Sitorus |
| author_facet | Santun Bhekti Rahimah Herri S. Sastramihardja Trully Detty Sitorus |
| author_sort | Santun Bhekti Rahimah |
| collection | DOAJ |
| description | Cigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels of malondialdehyde (MDA) and surface density (S/V) after exposure to cigarette smoke. The research used completed randomized design and á-tocopherol was used as control group. The dose of Pleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for 10 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (S/V) were observed on day 11th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MDA (0.4667+ 0.22295 nm/mL), as good as that of á-tocopherol(0,7467+ 0,24089 nm/mL). Ethanol extract also prevented the reduction of lung S/V (0.62283+0.4793) and it's effect was better from á-tocopherol (0.54683±0.39832), p=<0.05. In conclusion, our data shows that etanolic extract of Pleurotus ostreatus is a strong antioxidant that have better effect than á-tocopherol in preventing oxidative damage of cigarette smoke |
| first_indexed | 2024-12-14T13:39:18Z |
| format | Article |
| id | doaj.art-a7b70c4a2da8476ca9ada386175822f0 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-14T13:39:18Z |
| publishDate | 2010-12-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-a7b70c4a2da8476ca9ada386175822f02022-12-21T22:59:30ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232010-12-0142419520110.15395/mkb.v42n4.36Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap RokokSantun Bhekti Rahimah0Herri S. Sastramihardja1Trully Detty Sitorus2Bagian Farmakologi Fakultas Kedokteran Universitas Islam BandungDepartemen Farmakologi Fakultas Kedokteran Universitas PadjadjaranDepartemen Farmakologi Fakultas Kedokteran Universitas PadjadjaranCigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels of malondialdehyde (MDA) and surface density (S/V) after exposure to cigarette smoke. The research used completed randomized design and á-tocopherol was used as control group. The dose of Pleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for 10 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (S/V) were observed on day 11th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MDA (0.4667+ 0.22295 nm/mL), as good as that of á-tocopherol(0,7467+ 0,24089 nm/mL). Ethanol extract also prevented the reduction of lung S/V (0.62283+0.4793) and it's effect was better from á-tocopherol (0.54683±0.39832), p=<0.05. In conclusion, our data shows that etanolic extract of Pleurotus ostreatus is a strong antioxidant that have better effect than á-tocopherol in preventing oxidative damage of cigarette smokehttp://journal.fk.unpad.ac.id/index.php/mkb/article/view/36Cigarette smokefree radicalPleurotus ostreatusmalondyaldehydeS/V |
| spellingShingle | Santun Bhekti Rahimah Herri S. Sastramihardja Trully Detty Sitorus Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok Majalah Kedokteran Bandung Cigarette smoke free radical Pleurotus ostreatus malondyaldehyde S/V |
| title | Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok |
| title_full | Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok |
| title_fullStr | Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok |
| title_full_unstemmed | Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok |
| title_short | Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok |
| title_sort | efek antioksidan jamur tiram putih pada kadar malondialdehid dan kepadatan permukaan sel paru tikus yang terpapar asap rokok |
| topic | Cigarette smoke free radical Pleurotus ostreatus malondyaldehyde S/V |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/36 |
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