Complex interplay between p53 and chromosome stability
TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1938479 |
| _version_ | 1797677096608202752 |
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| author | Akshay Narkar Blake A. Johnson Rong Li |
| author_facet | Akshay Narkar Blake A. Johnson Rong Li |
| author_sort | Akshay Narkar |
| collection | DOAJ |
| description | TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we confirmed that p53 is required for high mitotic fidelity. Our findings provide a revised view on how p53 safeguards against aneuploidy. |
| first_indexed | 2024-03-11T22:40:06Z |
| format | Article |
| id | doaj.art-a7b78f8191ab4b69a9029a3db28d7a5c |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:06Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-a7b78f8191ab4b69a9029a3db28d7a5c2023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-07-018410.1080/23723556.2021.19384791938479Complex interplay between p53 and chromosome stabilityAkshay Narkar0Blake A. Johnson1Rong Li2Johns Hopkins University, School of MedicineJohns Hopkins University, School of MedicineJohns Hopkins University, School of MedicineTP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we confirmed that p53 is required for high mitotic fidelity. Our findings provide a revised view on how p53 safeguards against aneuploidy.http://dx.doi.org/10.1080/23723556.2021.1938479p53aneuploidyorganoids |
| spellingShingle | Akshay Narkar Blake A. Johnson Rong Li Complex interplay between p53 and chromosome stability Molecular & Cellular Oncology p53 aneuploidy organoids |
| title | Complex interplay between p53 and chromosome stability |
| title_full | Complex interplay between p53 and chromosome stability |
| title_fullStr | Complex interplay between p53 and chromosome stability |
| title_full_unstemmed | Complex interplay between p53 and chromosome stability |
| title_short | Complex interplay between p53 and chromosome stability |
| title_sort | complex interplay between p53 and chromosome stability |
| topic | p53 aneuploidy organoids |
| url | http://dx.doi.org/10.1080/23723556.2021.1938479 |
| work_keys_str_mv | AT akshaynarkar complexinterplaybetweenp53andchromosomestability AT blakeajohnson complexinterplaybetweenp53andchromosomestability AT rongli complexinterplaybetweenp53andchromosomestability |