Complex interplay between p53 and chromosome stability
TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we...
Main Authors: | Akshay Narkar, Blake A. Johnson, Rong Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2021-07-01
|
Series: | Molecular & Cellular Oncology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/23723556.2021.1938479 |
Similar Items
-
Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis
by: Xiufang Xiong, et al.
Published: (2014-08-01) -
p53 Isoforms and Their Implications in Cancer
by: Maximilian Vieler, et al.
Published: (2018-08-01) -
Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes
by: Lev Zavileyskiy, et al.
Published: (2022-02-01) -
Cell quiescence in planarian stem cells, interplay between p53 and nutritional stimuli
by: Gaetana Gambino, et al.
Published: (2022-12-01) -
The Underestimated Role of the p53 Pathway in Renal Cancer
by: Alessandra Amendolare, et al.
Published: (2022-11-01)