Multiple sclerosis: current state
Etiology of multiple sclerosis has both genetic and environmental components. The current conception is that multiple sclerosis pathogenesis comprises an initial inflammatory phase, followed by a phase of demyelination and last, a neurodegenerativephase. The mechanisms of inflammatory reactions, axo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/380/286 |
| Summary: | Etiology of multiple sclerosis has both genetic and environmental components. The current conception is that multiple sclerosis pathogenesis comprises an initial inflammatory phase, followed by a phase of demyelination and last, a neurodegenerativephase. The mechanisms of inflammatory reactions, axonal lossand reparative changes have been discussed. There are two schemes of treatments: the escalating approach and the inductiontherapy. One of the main principles of disease modifying therapy of MS is treat-early approach. Results of interferons-b andglatiramer acetate comparison as first-line MS therapy havebeen described. The use immunosuppressive agents and futuredevelopments of MS therapy have been discussed. |
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| ISSN: | 2075-5473 2409-2533 |