Importance of Efferocytosis in COVID-19 Mortality
Adnan Erol Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, TurkeyCorrespondence: Adnan Erol, Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, Turkey, Email eroladnan@protonmail.comAbstract: COVID-19 is a generally benign coronavirus disease th...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-03-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/importance-of-efferocytosis-in-covid-19-mortality-peer-reviewed-fulltext-article-IDR |
| _version_ | 1818690979270492160 |
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| author | Erol A |
| author_facet | Erol A |
| author_sort | Erol A |
| collection | DOAJ |
| description | Adnan Erol Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, TurkeyCorrespondence: Adnan Erol, Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, Turkey, Email eroladnan@protonmail.comAbstract: COVID-19 is a generally benign coronavirus disease that can spread rapidly, except for those with a group of risk factors. Since the pathogenesis responsible for the severity of the disease has not been clearly revealed, effective treatment alternatives has not been developed. The hallmark of the SARS-CoV-2-infected cells is apoptosis. Apoptotic cells are cleared through a sterile process defined as efferocytosis by professional and nonprofessional phagocytic cells. The disease would be rapidly brought under control in the organism that can achieve effective efferocytosis, which is also a kind of innate immune response. In the risk group, the efferocytic process is defective. With the addition of the apoptotic cell load associated with SARS-COV-2 infection, failure to achieve efferocytosis of dying cells can initiate secondary necrosis, which is a highly destructive process. Uncontrolled inflammation and coagulation abnormalities caused by secondary necrosis reason in various organ failures, lung in particular, which are responsible for the poor prognosis. Following the short and simplified information, this opinion paper aims to present possible treatment options that can control the severity of COVID-19 by detailing the mechanisms that can cause defective efferocytosis.Graphical Abstract: Keywords: COVID-19, SARS-CoV-2, efferocytosis: ADAM17, phosphatidylserine |
| first_indexed | 2024-12-17T12:34:36Z |
| format | Article |
| id | doaj.art-a7b7c7fee2d1413b9a5761f404ad71e2 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-17T12:34:36Z |
| publishDate | 2022-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-a7b7c7fee2d1413b9a5761f404ad71e22022-12-21T21:48:23ZengDove Medical PressInfection and Drug Resistance1178-69732022-03-01Volume 15995100773607Importance of Efferocytosis in COVID-19 MortalityErol AAdnan Erol Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, TurkeyCorrespondence: Adnan Erol, Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, Turkey, Email eroladnan@protonmail.comAbstract: COVID-19 is a generally benign coronavirus disease that can spread rapidly, except for those with a group of risk factors. Since the pathogenesis responsible for the severity of the disease has not been clearly revealed, effective treatment alternatives has not been developed. The hallmark of the SARS-CoV-2-infected cells is apoptosis. Apoptotic cells are cleared through a sterile process defined as efferocytosis by professional and nonprofessional phagocytic cells. The disease would be rapidly brought under control in the organism that can achieve effective efferocytosis, which is also a kind of innate immune response. In the risk group, the efferocytic process is defective. With the addition of the apoptotic cell load associated with SARS-COV-2 infection, failure to achieve efferocytosis of dying cells can initiate secondary necrosis, which is a highly destructive process. Uncontrolled inflammation and coagulation abnormalities caused by secondary necrosis reason in various organ failures, lung in particular, which are responsible for the poor prognosis. Following the short and simplified information, this opinion paper aims to present possible treatment options that can control the severity of COVID-19 by detailing the mechanisms that can cause defective efferocytosis.Graphical Abstract: Keywords: COVID-19, SARS-CoV-2, efferocytosis: ADAM17, phosphatidylserinehttps://www.dovepress.com/importance-of-efferocytosis-in-covid-19-mortality-peer-reviewed-fulltext-article-IDRcovid-19sars-cov-2efferocytosis: adam17phosphatidylserine |
| spellingShingle | Erol A Importance of Efferocytosis in COVID-19 Mortality Infection and Drug Resistance covid-19 sars-cov-2 efferocytosis: adam17 phosphatidylserine |
| title | Importance of Efferocytosis in COVID-19 Mortality |
| title_full | Importance of Efferocytosis in COVID-19 Mortality |
| title_fullStr | Importance of Efferocytosis in COVID-19 Mortality |
| title_full_unstemmed | Importance of Efferocytosis in COVID-19 Mortality |
| title_short | Importance of Efferocytosis in COVID-19 Mortality |
| title_sort | importance of efferocytosis in covid 19 mortality |
| topic | covid-19 sars-cov-2 efferocytosis: adam17 phosphatidylserine |
| url | https://www.dovepress.com/importance-of-efferocytosis-in-covid-19-mortality-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT erola importanceofefferocytosisincovid19mortality |