The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review
Schizophrenia is a severe neuropsychiatric disease with an unknown etiology. The research into the neurobiology of this disease led to several models aimed at explaining the link between perturbations in brain function and the manifestation of psychotic symptoms. The glutamatergic hypothesis postula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1475 |
| _version_ | 1797538979229204480 |
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| author | Waldemar Kryszkowski Tomasz Boczek |
| author_facet | Waldemar Kryszkowski Tomasz Boczek |
| author_sort | Waldemar Kryszkowski |
| collection | DOAJ |
| description | Schizophrenia is a severe neuropsychiatric disease with an unknown etiology. The research into the neurobiology of this disease led to several models aimed at explaining the link between perturbations in brain function and the manifestation of psychotic symptoms. The glutamatergic hypothesis postulates that disrupted glutamate neurotransmission may mediate cognitive and psychosocial impairments by affecting the connections between the cortex and the thalamus. In this regard, the greatest attention has been given to ionotropic NMDA receptor hypofunction. However, converging data indicates metabotropic glutamate receptors as crucial for cognitive and psychomotor function. The distribution of these receptors in the brain regions related to schizophrenia and their regulatory role in glutamate release make them promising molecular targets for novel antipsychotics. This article reviews the progress in the research on the role of metabotropic glutamate receptors in schizophrenia etiopathology. |
| first_indexed | 2024-03-10T12:39:51Z |
| format | Article |
| id | doaj.art-a7b856f697db445e9bfba9b28981c7b7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:39:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a7b856f697db445e9bfba9b28981c7b72023-11-21T14:00:53ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01107147510.3390/jcm10071475The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative ReviewWaldemar Kryszkowski0Tomasz Boczek1General Psychiatric Ward, Babinski Memorial Hospital in Lodz, 91229 Lodz, PolandDepartment of Molecular Neurochemistry, Medical University of Lodz, 92215 Lodz, PolandSchizophrenia is a severe neuropsychiatric disease with an unknown etiology. The research into the neurobiology of this disease led to several models aimed at explaining the link between perturbations in brain function and the manifestation of psychotic symptoms. The glutamatergic hypothesis postulates that disrupted glutamate neurotransmission may mediate cognitive and psychosocial impairments by affecting the connections between the cortex and the thalamus. In this regard, the greatest attention has been given to ionotropic NMDA receptor hypofunction. However, converging data indicates metabotropic glutamate receptors as crucial for cognitive and psychomotor function. The distribution of these receptors in the brain regions related to schizophrenia and their regulatory role in glutamate release make them promising molecular targets for novel antipsychotics. This article reviews the progress in the research on the role of metabotropic glutamate receptors in schizophrenia etiopathology.https://www.mdpi.com/2077-0383/10/7/1475schizophreniametabotropic glutamate receptorspositive allosteric modulatorsnegative allosteric modulatorsdrug developmentanimal models of schizophrenia |
| spellingShingle | Waldemar Kryszkowski Tomasz Boczek The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review Journal of Clinical Medicine schizophrenia metabotropic glutamate receptors positive allosteric modulators negative allosteric modulators drug development animal models of schizophrenia |
| title | The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review |
| title_full | The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review |
| title_fullStr | The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review |
| title_full_unstemmed | The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review |
| title_short | The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review |
| title_sort | g protein coupled glutamate receptors as novel molecular targets in schizophrenia treatment a narrative review |
| topic | schizophrenia metabotropic glutamate receptors positive allosteric modulators negative allosteric modulators drug development animal models of schizophrenia |
| url | https://www.mdpi.com/2077-0383/10/7/1475 |
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