Microbicidal Phagocytosis of Nucleus Pulposus Cells Against Staphylococcus aureus via the TLR2/MAPKs Signaling Pathway

Microbicidal Phagocytosis of Nucleus Pulposus Cells Against Staphylococcus aureus via the TLR2/MAPKs Signaling Pathway

Intervertebral disc (IVD) is an immune-privileged organ that lacks immunocytes, such as macrophages or neutrophils; therefore, it is unclear how IVD immunological defense against bacterial infection occurs. Here, we demonstrated that nucleus pulposus cells (NPCs), the vital machinery for maintaining...

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Bibliographic Details
Main Authors: Yazhou Lin, Hui Cong, Kewei Liu, Yucheng Jiao, Ye Yuan, Guoqing Tang, Yong Chen, Yuehuan Zheng, Jiaqi Xiao, Changwei Li, Zhe Chen, Peng Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
nucleus pulposus cells
phagocytosis
phagolysosomes
Staphylococcus aureus
TLR2
MAPKs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01132/full

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