Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases
Objective To summarize the clinical features and the outcome of surgical treatment of refractory secondary hyperparathyroidism (SHPT) after dialysis in patients with chronic kidney disease (CKD). Methods A study was conducted on 102 CKD patients with refractory SHPT after dialysis who received surgi...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Army Medical University
2022-12-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202208102.htm |
| _version_ | 1797974781564289024 |
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| author | HE Yun CHENG Yifan TIAN Hao |
| author_facet | HE Yun CHENG Yifan TIAN Hao |
| author_sort | HE Yun |
| collection | DOAJ |
| description | Objective To summarize the clinical features and the outcome of surgical treatment of refractory secondary hyperparathyroidism (SHPT) after dialysis in patients with chronic kidney disease (CKD). Methods A study was conducted on 102 CKD patients with refractory SHPT after dialysis who received surgical treatment in our hospital from January 2018 to December 2019. The clinical characteristics including hematological indicators were analyzed. The treatment outcome and postoperative complications were summarized. Results The decrement of parathyroid hormone (PTH) level on postoperative day 1 was higher than 80% of preoperative PTH level. On postoperative day 1 and day 7 and month 3, the serum levels of calcium, phosphorus and PTH were significantly decreased when compared with the preoperative values. There were 4 cases having thyroidectomy, 20 cases experincing central lymph node dissection, and 10 cases undergoing thymus resection. During the perioperative period, 15 patients had numbness on hands, feet and perioral area, and 2 of them had distal upper extremity convulsion. The systemic symptoms were greatly relieved in 99 patients within 1 week after surgery. There were 5 cases of permanent hypoparathyroidism and 2 cases of recurrent SHPT after operation. Conclusion Surgery is the most effective treatment for refractory SHPT. Multiple imaging examinations should be used to locate parathyroid gland, and detailed evaluation should be conducted preoperatively. During postoperative period, hematological indicators should be closely monitored and timely treatment of complications is necessary.
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| first_indexed | 2024-04-11T04:24:08Z |
| format | Article |
| id | doaj.art-a7bafc41e797427d82f90b05c36d7b8d |
| institution | Directory Open Access Journal |
| issn | 2097-0927 |
| language | zho |
| last_indexed | 2024-04-11T04:24:08Z |
| publishDate | 2022-12-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj.art-a7bafc41e797427d82f90b05c36d7b8d2022-12-30T03:09:23ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272022-12-0144242530253610.16016/j.2097-0927.202208102Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 casesHE Yun0CHENG Yifan1TIAN Hao2Department of Ultrasound, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaDepartment of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaDepartment of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaObjective To summarize the clinical features and the outcome of surgical treatment of refractory secondary hyperparathyroidism (SHPT) after dialysis in patients with chronic kidney disease (CKD). Methods A study was conducted on 102 CKD patients with refractory SHPT after dialysis who received surgical treatment in our hospital from January 2018 to December 2019. The clinical characteristics including hematological indicators were analyzed. The treatment outcome and postoperative complications were summarized. Results The decrement of parathyroid hormone (PTH) level on postoperative day 1 was higher than 80% of preoperative PTH level. On postoperative day 1 and day 7 and month 3, the serum levels of calcium, phosphorus and PTH were significantly decreased when compared with the preoperative values. There were 4 cases having thyroidectomy, 20 cases experincing central lymph node dissection, and 10 cases undergoing thymus resection. During the perioperative period, 15 patients had numbness on hands, feet and perioral area, and 2 of them had distal upper extremity convulsion. The systemic symptoms were greatly relieved in 99 patients within 1 week after surgery. There were 5 cases of permanent hypoparathyroidism and 2 cases of recurrent SHPT after operation. Conclusion Surgery is the most effective treatment for refractory SHPT. Multiple imaging examinations should be used to locate parathyroid gland, and detailed evaluation should be conducted preoperatively. During postoperative period, hematological indicators should be closely monitored and timely treatment of complications is necessary. http://aammt.tmmu.edu.cn/Upload/rhtml/202208102.htmchronic kidney diseaserefractory secondary hyperparathyroidismsurgical treatment outcometotal parathyroidectomy |
| spellingShingle | HE Yun CHENG Yifan TIAN Hao Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases 陆军军医大学学报 chronic kidney disease refractory secondary hyperparathyroidism surgical treatment outcome total parathyroidectomy |
| title | Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases |
| title_full | Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases |
| title_fullStr | Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases |
| title_full_unstemmed | Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases |
| title_short | Surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis: a case series report series of 120 cases |
| title_sort | surgical treatment for refractory secondary hyperparathyroidism in chronic kidney disease patients after dialysis a case series report series of 120 cases |
| topic | chronic kidney disease refractory secondary hyperparathyroidism surgical treatment outcome total parathyroidectomy |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202208102.htm |
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