PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines

PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines

Glioblastomas are highly resistant to radiation and chemotherapy. Currently, there are no effective therapies for this type of tumor. Signaling mechanisms initiated by PDGFR and IGF-1R are important in glioblastoma, and inhibition of the signal transduction pathways initiated by these receptors coul...

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Bibliographic Details
Main Authors: Estefania Carrasco-Garcia, Isabel Martinez-Lacaci, Leticia Mayor-López, Elena Tristante, Mar Carballo-Santana, Pilar García-Morales, Maria Paz Ventero Martin, Maria Fuentes-Baile, Álvaro Rodriguez-Lescure, Miguel Saceda
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
glioblastoma
PDFGR
IGF-1R
cell death
Online Access:http://www.mdpi.com/2073-4409/7/9/131

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