Diacerein for osteoarthritis: An open-label comparative trial
Osteoarthritis (OA) is a degenerative joint disease that is accompanied by cartilage destruction, synovial membrane inflammatory changes, and subchondral bone remodeling.Objective: to perform comparative evaluation of the efficiency of knee OA treatment with diacerein, hyaluronic acid, and nonsteroi...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2016-03-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/666 |
| _version_ | 1797876766488920064 |
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| author | L. V. Luchikhina D. E. Karateev |
| author_facet | L. V. Luchikhina D. E. Karateev |
| author_sort | L. V. Luchikhina |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a degenerative joint disease that is accompanied by cartilage destruction, synovial membrane inflammatory changes, and subchondral bone remodeling.Objective: to perform comparative evaluation of the efficiency of knee OA treatment with diacerein, hyaluronic acid, and nonsteroidal antiinflammatory drugs at short- and long-term follow-up.Patients and methods. An open-label comparative enrolled 192 patients with knee arthritis: 68.5% women and 31.5% men (mean age, 52.7±1.79 years; mean disease duration, 7 years). The patients were divided into three groups matched for gender, age, and disease duration: Group 1 (n=63) took diacerein 100 mg/day; Group 2 (n=65) received intraarticular hyaluronic acid 2 ml thrice at an interval of 7 days; Group 3 (n=64) had diclofenac 75 mg/day. The patients of all the three groups had a similar magnitude of its symptoms and Kellgren grade. Magnetic resonance imaging (MRI) and arthroscopic examination of the knee joint were performed to assess the results of treatment in the patients.Results. To evaluate the chondroprotective effect of the drugs, the authors used their proposed arthroscopic and MRI criteria (sensitivity, 89.7%; specificity, 93.1%) that allow abnormally changed and normal cartilages to be identified. At months 2 of treatment, all the three drugs ensured a considerable pain intensity reduction that persisted till 12 weeks. The important benefit of diacerein and hyaluronic acid was their aftereffect for further 3 months. |
| first_indexed | 2024-04-10T02:07:46Z |
| format | Article |
| id | doaj.art-a7bfa7ce003b4c35bf2303cab04507ee |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:07:46Z |
| publishDate | 2016-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-a7bfa7ce003b4c35bf2303cab04507ee2023-03-13T08:39:24ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2016-03-01101212510.14412/1996-7012-2016-1-21-251958Diacerein for osteoarthritis: An open-label comparative trialL. V. Luchikhina0D. E. Karateev1ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Городская клиническая больница № 31,ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Osteoarthritis (OA) is a degenerative joint disease that is accompanied by cartilage destruction, synovial membrane inflammatory changes, and subchondral bone remodeling.Objective: to perform comparative evaluation of the efficiency of knee OA treatment with diacerein, hyaluronic acid, and nonsteroidal antiinflammatory drugs at short- and long-term follow-up.Patients and methods. An open-label comparative enrolled 192 patients with knee arthritis: 68.5% women and 31.5% men (mean age, 52.7±1.79 years; mean disease duration, 7 years). The patients were divided into three groups matched for gender, age, and disease duration: Group 1 (n=63) took diacerein 100 mg/day; Group 2 (n=65) received intraarticular hyaluronic acid 2 ml thrice at an interval of 7 days; Group 3 (n=64) had diclofenac 75 mg/day. The patients of all the three groups had a similar magnitude of its symptoms and Kellgren grade. Magnetic resonance imaging (MRI) and arthroscopic examination of the knee joint were performed to assess the results of treatment in the patients.Results. To evaluate the chondroprotective effect of the drugs, the authors used their proposed arthroscopic and MRI criteria (sensitivity, 89.7%; specificity, 93.1%) that allow abnormally changed and normal cartilages to be identified. At months 2 of treatment, all the three drugs ensured a considerable pain intensity reduction that persisted till 12 weeks. The important benefit of diacerein and hyaluronic acid was their aftereffect for further 3 months.https://mrj.ima-press.net/mrj/article/view/666остеоартрозлечениедиацереинпрепараты гиалуроновой кислотыдиклофенакхондропротективное действие |
| spellingShingle | L. V. Luchikhina D. E. Karateev Diacerein for osteoarthritis: An open-label comparative trial Современная ревматология остеоартроз лечение диацереин препараты гиалуроновой кислоты диклофенак хондропротективное действие |
| title | Diacerein for osteoarthritis: An open-label comparative trial |
| title_full | Diacerein for osteoarthritis: An open-label comparative trial |
| title_fullStr | Diacerein for osteoarthritis: An open-label comparative trial |
| title_full_unstemmed | Diacerein for osteoarthritis: An open-label comparative trial |
| title_short | Diacerein for osteoarthritis: An open-label comparative trial |
| title_sort | diacerein for osteoarthritis an open label comparative trial |
| topic | остеоартроз лечение диацереин препараты гиалуроновой кислоты диклофенак хондропротективное действие |
| url | https://mrj.ima-press.net/mrj/article/view/666 |
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