Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial
Background: Prevalence of migraine, as a chronic neurovascular disorder, was approximately 10.3 and 23.1% among men and women, respectively, mostly in people younger than 40 years old. Migraine is prevalent in different geographic areas worldwide. The present study was designed to compare the impact...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=121;epage=121;aulast=Rafieian-kopaei |
| _version_ | 1818312276403290112 |
|---|---|
| author | Mahmood Rafieian-kopaei Ali Hasanpour-dehkordi Zahra Lorigooini Fatemeh Deris Kamal Solati Faezeh Mahdiyeh |
| author_facet | Mahmood Rafieian-kopaei Ali Hasanpour-dehkordi Zahra Lorigooini Fatemeh Deris Kamal Solati Faezeh Mahdiyeh |
| author_sort | Mahmood Rafieian-kopaei |
| collection | DOAJ |
| description | Background: Prevalence of migraine, as a chronic neurovascular disorder, was approximately 10.3 and 23.1% among men and women, respectively, mostly in people younger than 40 years old. Migraine is prevalent in different geographic areas worldwide. The present study was designed to compare the impact of intranasal lidocaine 4% and peppermint essential oil drop 1.5% on migraine attacks. Methods: In this double-blind, parallel, randomized controlled trial, 120 adult patients with a diagnosis of migraine based on the International Headache Society criteria were treated with intranasal lidocaine drop 4% or peppermint essential oil drop 1.5% or placebo. Patients expressed their symptoms 5 and 15 min after dripping, and if they still had a headache after 15 min, they were given the second dose. Patients with a second dose of medication, 15 min later recorded their headache rate. All patients recorded their symptoms after 30 min. Symptoms of the patients were followed by a researcher through the phone and in-person after 2 months. Then, the questionnaires were filled. Results: In the present study, there was a significant difference among groups in headache intensity after treatment (P < 0.001). In 40% of the patients in the peppermint oil and lidocaine groups, the intensity of headache decreased. In the placebo group, fewer patients responded highly to the treatment, whereas 41.5% of patients in the lidocaine group and 42.1% of patients in the peppermint oil group responded to the treatment considerably. Conclusions: Concerning the findings of the present study, nasal application of peppermint oil caused considerable reduction in the intensity and frequency of headache and relieved majority of patients' pain similar to lidocaine. On the basis of findings of this study, it can be concluded that nasal menthol, such as lidocaine, can be used to relieve migraine headaches. |
| first_indexed | 2024-12-13T08:15:17Z |
| format | Article |
| id | doaj.art-a7bfe320646c41fd9f99a8552b5970d3 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-12-13T08:15:17Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-a7bfe320646c41fd9f99a8552b5970d32022-12-21T23:54:07ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132019-01-0110112112110.4103/ijpvm.IJPVM_530_17Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trialMahmood Rafieian-kopaeiAli Hasanpour-dehkordiZahra LorigooiniFatemeh DerisKamal SolatiFaezeh MahdiyehBackground: Prevalence of migraine, as a chronic neurovascular disorder, was approximately 10.3 and 23.1% among men and women, respectively, mostly in people younger than 40 years old. Migraine is prevalent in different geographic areas worldwide. The present study was designed to compare the impact of intranasal lidocaine 4% and peppermint essential oil drop 1.5% on migraine attacks. Methods: In this double-blind, parallel, randomized controlled trial, 120 adult patients with a diagnosis of migraine based on the International Headache Society criteria were treated with intranasal lidocaine drop 4% or peppermint essential oil drop 1.5% or placebo. Patients expressed their symptoms 5 and 15 min after dripping, and if they still had a headache after 15 min, they were given the second dose. Patients with a second dose of medication, 15 min later recorded their headache rate. All patients recorded their symptoms after 30 min. Symptoms of the patients were followed by a researcher through the phone and in-person after 2 months. Then, the questionnaires were filled. Results: In the present study, there was a significant difference among groups in headache intensity after treatment (P < 0.001). In 40% of the patients in the peppermint oil and lidocaine groups, the intensity of headache decreased. In the placebo group, fewer patients responded highly to the treatment, whereas 41.5% of patients in the lidocaine group and 42.1% of patients in the peppermint oil group responded to the treatment considerably. Conclusions: Concerning the findings of the present study, nasal application of peppermint oil caused considerable reduction in the intensity and frequency of headache and relieved majority of patients' pain similar to lidocaine. On the basis of findings of this study, it can be concluded that nasal menthol, such as lidocaine, can be used to relieve migraine headaches.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=121;epage=121;aulast=Rafieian-kopaeiheadachelidocainemigraine attackspeppermint oil |
| spellingShingle | Mahmood Rafieian-kopaei Ali Hasanpour-dehkordi Zahra Lorigooini Fatemeh Deris Kamal Solati Faezeh Mahdiyeh Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial International Journal of Preventive Medicine headache lidocaine migraine attacks peppermint oil |
| title | Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial |
| title_full | Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial |
| title_fullStr | Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial |
| title_full_unstemmed | Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial |
| title_short | Comparing the effect of intranasal lidocaine 4% with peppermint essential oil drop 1.5% on migraine attacks: A double-blind clinical trial |
| title_sort | comparing the effect of intranasal lidocaine 4 with peppermint essential oil drop 1 5 on migraine attacks a double blind clinical trial |
| topic | headache lidocaine migraine attacks peppermint oil |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=121;epage=121;aulast=Rafieian-kopaei |
| work_keys_str_mv | AT mahmoodrafieiankopaei comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial AT alihasanpourdehkordi comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial AT zahralorigooini comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial AT fatemehderis comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial AT kamalsolati comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial AT faezehmahdiyeh comparingtheeffectofintranasallidocaine4withpeppermintessentialoildrop15onmigraineattacksadoubleblindclinicaltrial |