West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement
Abstract Background West Nile virus (WNV) is endemic in southeastern Romania and, after the unprecedented urban epidemic in Bucharest in 1996 caused by lineage 1 WNV, cases of West Nile fever have been recorded every year. Furthermore, a new outbreak occurred in 2010, this time produced by a lineage...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-018-3145-5 |
| _version_ | 1818193809308123136 |
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| author | Ani Ioana Cotar Elena Fălcuță Sorin Dinu Adriana Necula Victoria Bîrluțiu Cornelia Svetlana Ceianu Florian Liviu Prioteasa |
| author_facet | Ani Ioana Cotar Elena Fălcuță Sorin Dinu Adriana Necula Victoria Bîrluțiu Cornelia Svetlana Ceianu Florian Liviu Prioteasa |
| author_sort | Ani Ioana Cotar |
| collection | DOAJ |
| description | Abstract Background West Nile virus (WNV) is endemic in southeastern Romania and, after the unprecedented urban epidemic in Bucharest in 1996 caused by lineage 1 WNV, cases of West Nile fever have been recorded every year. Furthermore, a new outbreak occurred in 2010, this time produced by a lineage 2 WNV belonging to the Eastern European clade (Volgograd 2007-like strain), which was detected in humans and mosquitoes in the following years. Results We report here, for the first time, the emergence, in 2015, of lineage 2 WNV belonging to the monophyletic Central/Southern European group of strains which replaced in 2016, the previously endemized lineage 2 WNV Volgograd 2007-like strain in mosquito populations. The emerged WNV strain harbors H249P (NS3 protein) and I159T (E glycoprotein) substitutions, which have been previously associated in other studies with neurovirulence and efficient vector transmission. Conclusions In 2016, both early amplification of the emerged WNV and complete replacement in mosquito populations of the previously endemized WNV occurred in southeastern Romania. These events were associated with a significant outbreak of severe West Nile neuroinvasive disease in humans. |
| first_indexed | 2024-12-12T00:52:18Z |
| format | Article |
| id | doaj.art-a7c2358efadf495f93088fc55c755001 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-12T00:52:18Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-a7c2358efadf495f93088fc55c7550012022-12-22T00:43:58ZengBMCParasites & Vectors1756-33052018-10-011111510.1186/s13071-018-3145-5West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacementAni Ioana Cotar0Elena Fălcuță1Sorin Dinu2Adriana Necula3Victoria Bîrluțiu4Cornelia Svetlana Ceianu5Florian Liviu Prioteasa6Cantacuzino National Medico-Military Institute for Research and DevelopmentCantacuzino National Medico-Military Institute for Research and DevelopmentCantacuzino National Medico-Military Institute for Research and DevelopmentNational Institute of Blood TransfusionFaculty of Medicine, Lucian Blaga UniversityCantacuzino National Medico-Military Institute for Research and DevelopmentCantacuzino National Medico-Military Institute for Research and DevelopmentAbstract Background West Nile virus (WNV) is endemic in southeastern Romania and, after the unprecedented urban epidemic in Bucharest in 1996 caused by lineage 1 WNV, cases of West Nile fever have been recorded every year. Furthermore, a new outbreak occurred in 2010, this time produced by a lineage 2 WNV belonging to the Eastern European clade (Volgograd 2007-like strain), which was detected in humans and mosquitoes in the following years. Results We report here, for the first time, the emergence, in 2015, of lineage 2 WNV belonging to the monophyletic Central/Southern European group of strains which replaced in 2016, the previously endemized lineage 2 WNV Volgograd 2007-like strain in mosquito populations. The emerged WNV strain harbors H249P (NS3 protein) and I159T (E glycoprotein) substitutions, which have been previously associated in other studies with neurovirulence and efficient vector transmission. Conclusions In 2016, both early amplification of the emerged WNV and complete replacement in mosquito populations of the previously endemized WNV occurred in southeastern Romania. These events were associated with a significant outbreak of severe West Nile neuroinvasive disease in humans.http://link.springer.com/article/10.1186/s13071-018-3145-5Lineage 2 West Nile virusEastern European cladeCentral/Southern European cladeCo-circulationStrain replacement |
| spellingShingle | Ani Ioana Cotar Elena Fălcuță Sorin Dinu Adriana Necula Victoria Bîrluțiu Cornelia Svetlana Ceianu Florian Liviu Prioteasa West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement Parasites & Vectors Lineage 2 West Nile virus Eastern European clade Central/Southern European clade Co-circulation Strain replacement |
| title | West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement |
| title_full | West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement |
| title_fullStr | West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement |
| title_full_unstemmed | West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement |
| title_short | West Nile virus lineage 2 in Romania, 2015–2016: co-circulation and strain replacement |
| title_sort | west nile virus lineage 2 in romania 2015 2016 co circulation and strain replacement |
| topic | Lineage 2 West Nile virus Eastern European clade Central/Southern European clade Co-circulation Strain replacement |
| url | http://link.springer.com/article/10.1186/s13071-018-3145-5 |
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