Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System
The human body is host to large numbers of bacteriophages (phages)–a diverse group of bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that only impacted immunity indirectly via effects on the mammalian microbiome. However, it has become clear that phage...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/11/1/10 |
| _version_ | 1818213849345556480 |
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| author | Jonas D. Van Belleghem Krystyna Dąbrowska Mario Vaneechoutte Jeremy J. Barr Paul L. Bollyky |
| author_facet | Jonas D. Van Belleghem Krystyna Dąbrowska Mario Vaneechoutte Jeremy J. Barr Paul L. Bollyky |
| author_sort | Jonas D. Van Belleghem |
| collection | DOAJ |
| description | The human body is host to large numbers of bacteriophages (phages)–a diverse group of bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that only impacted immunity indirectly via effects on the mammalian microbiome. However, it has become clear that phages also impact immunity directly, in ways that are typically anti-inflammatory. Phages can modulate innate immunity via phagocytosis and cytokine responses, but also impact adaptive immunity via effects on antibody production and effector polarization. Phages may thereby have profound effects on the outcome of bacterial infections by modulating the immune response. In this review we highlight the diverse ways in which phages interact with human cells. We present a computational model for predicting these complex and dynamic interactions. These models predict that the phageome may play important roles in shaping mammalian-bacterial interactions. |
| first_indexed | 2024-12-12T06:10:49Z |
| format | Article |
| id | doaj.art-a7c23f8e832d406f80d2c9b6f6b0c3aa |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-12T06:10:49Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a7c23f8e832d406f80d2c9b6f6b0c3aa2022-12-22T00:35:10ZengMDPI AGViruses1999-49152018-12-011111010.3390/v11010010v11010010Interactions between Bacteriophage, Bacteria, and the Mammalian Immune SystemJonas D. Van Belleghem0Krystyna Dąbrowska1Mario Vaneechoutte2Jeremy J. Barr3Paul L. Bollyky4Laboratory Bacteriology Research, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, 9000 Ghent, BelgiumBacteriophage Laboratory, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, PolandLaboratory Bacteriology Research, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, 9000 Ghent, BelgiumSchool of Biological Sciences, Monash University, Melbourne, VIC 3800, AustraliaDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USAThe human body is host to large numbers of bacteriophages (phages)–a diverse group of bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that only impacted immunity indirectly via effects on the mammalian microbiome. However, it has become clear that phages also impact immunity directly, in ways that are typically anti-inflammatory. Phages can modulate innate immunity via phagocytosis and cytokine responses, but also impact adaptive immunity via effects on antibody production and effector polarization. Phages may thereby have profound effects on the outcome of bacterial infections by modulating the immune response. In this review we highlight the diverse ways in which phages interact with human cells. We present a computational model for predicting these complex and dynamic interactions. These models predict that the phageome may play important roles in shaping mammalian-bacterial interactions.http://www.mdpi.com/1999-4915/11/1/10bacteriophageimmunologyinnate immunityadaptive immunityhuman hostphage-human host interaction |
| spellingShingle | Jonas D. Van Belleghem Krystyna Dąbrowska Mario Vaneechoutte Jeremy J. Barr Paul L. Bollyky Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System Viruses bacteriophage immunology innate immunity adaptive immunity human host phage-human host interaction |
| title | Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System |
| title_full | Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System |
| title_fullStr | Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System |
| title_full_unstemmed | Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System |
| title_short | Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System |
| title_sort | interactions between bacteriophage bacteria and the mammalian immune system |
| topic | bacteriophage immunology innate immunity adaptive immunity human host phage-human host interaction |
| url | http://www.mdpi.com/1999-4915/11/1/10 |
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