Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study
Abstract Background Hypertriglyceridemic-waist (HTGW) phenotype has been proposed as a practical tool for screening the risk of cardiovascular diseases and glycemic metabolic disease. This study sought to investigate the relationship between HTGW phenotype and non-alcoholic fatty liver disease (NAFL...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-022-01660-8 |
| _version_ | 1818161940636106752 |
|---|---|
| author | Ming Yang Yaqin Xu Chong Hu Shuhua Zhang Maobin Kuang Yang Zou |
| author_facet | Ming Yang Yaqin Xu Chong Hu Shuhua Zhang Maobin Kuang Yang Zou |
| author_sort | Ming Yang |
| collection | DOAJ |
| description | Abstract Background Hypertriglyceridemic-waist (HTGW) phenotype has been proposed as a practical tool for screening the risk of cardiovascular diseases and glycemic metabolic disease. This study sought to investigate the relationship between HTGW phenotype and non-alcoholic fatty liver disease (NAFLD). Methods A total of 14,251 subjects who took part in health screening were enrolled in the study and NAFLD was diagnosed by abdominal ultrasound. According to triglyceride (TG) and waist circumference, the study population was divided into four phenotypes, in which HTGW phenotype was defined as TG ≥ 1.7 mmol/L and male waist circumference ≥ 90 cm or female waist circumference ≥ 80 cm. Multivariate logistic regression analysis was used to evaluate the relationship between HTGW phenotype and NAFLD. Results In the current study, 2.43% of the subjects had HTGW phenotype, while the prevalence of NAFLD in subjects with HTGW phenotype was 77.81%. After full adjustment for covariates, compared with people with normal waist circumference and TG levels, the risk of NAFLD in people with normal TG levels but enlarged waist circumference increased by 39% [OR:1.39, 95%CI: 1.15, 1.68], in people with normal waist circumference but elevated TG levels increased by 96% [OR:1.96, 95%CI: 1.65, 2.33], and in subjects with HTGW phenotype increased by 160% [OR:2.60, 95%CI: 1.88, 3.58]. Additionally, further analysis suggested that there were significant interactions between age, height, BMI and NAFLD risk associated with TGW phenotypes. Receiver operating characteristic curves analysis suggested that the combination of TG and waist circumference further improved the diagnostic value for NAFLD. Conclusions HTGW phenotype is associated with NAFLD risk in the general population, which may be a novel and accessible indicator for NAFLD screening. |
| first_indexed | 2024-12-11T16:25:45Z |
| format | Article |
| id | doaj.art-a7c3add5a8134e169aead4d20977f864 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T16:25:45Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a7c3add5a8134e169aead4d20977f8642022-12-22T00:58:45ZengBMCLipids in Health and Disease1476-511X2022-06-0121111010.1186/s12944-022-01660-8Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based studyMing Yang0Yaqin Xu1Chong Hu2Shuhua Zhang3Maobin Kuang4Yang Zou5Department of Cardiology, Jiangxi Provincial People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial People’s HospitalJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s HospitalJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s HospitalJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s HospitalAbstract Background Hypertriglyceridemic-waist (HTGW) phenotype has been proposed as a practical tool for screening the risk of cardiovascular diseases and glycemic metabolic disease. This study sought to investigate the relationship between HTGW phenotype and non-alcoholic fatty liver disease (NAFLD). Methods A total of 14,251 subjects who took part in health screening were enrolled in the study and NAFLD was diagnosed by abdominal ultrasound. According to triglyceride (TG) and waist circumference, the study population was divided into four phenotypes, in which HTGW phenotype was defined as TG ≥ 1.7 mmol/L and male waist circumference ≥ 90 cm or female waist circumference ≥ 80 cm. Multivariate logistic regression analysis was used to evaluate the relationship between HTGW phenotype and NAFLD. Results In the current study, 2.43% of the subjects had HTGW phenotype, while the prevalence of NAFLD in subjects with HTGW phenotype was 77.81%. After full adjustment for covariates, compared with people with normal waist circumference and TG levels, the risk of NAFLD in people with normal TG levels but enlarged waist circumference increased by 39% [OR:1.39, 95%CI: 1.15, 1.68], in people with normal waist circumference but elevated TG levels increased by 96% [OR:1.96, 95%CI: 1.65, 2.33], and in subjects with HTGW phenotype increased by 160% [OR:2.60, 95%CI: 1.88, 3.58]. Additionally, further analysis suggested that there were significant interactions between age, height, BMI and NAFLD risk associated with TGW phenotypes. Receiver operating characteristic curves analysis suggested that the combination of TG and waist circumference further improved the diagnostic value for NAFLD. Conclusions HTGW phenotype is associated with NAFLD risk in the general population, which may be a novel and accessible indicator for NAFLD screening.https://doi.org/10.1186/s12944-022-01660-8Non-alcoholic fatty liver diseaseHypertriglyceridemic-waist phenotypeHTGWGeneral populationTriglycerideWaist circumference |
| spellingShingle | Ming Yang Yaqin Xu Chong Hu Shuhua Zhang Maobin Kuang Yang Zou Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study Lipids in Health and Disease Non-alcoholic fatty liver disease Hypertriglyceridemic-waist phenotype HTGW General population Triglyceride Waist circumference |
| title | Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study |
| title_full | Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study |
| title_fullStr | Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study |
| title_full_unstemmed | Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study |
| title_short | Association between hypertriglyceridemic-waist phenotype and non-alcoholic fatty liver disease: a general population-based study |
| title_sort | association between hypertriglyceridemic waist phenotype and non alcoholic fatty liver disease a general population based study |
| topic | Non-alcoholic fatty liver disease Hypertriglyceridemic-waist phenotype HTGW General population Triglyceride Waist circumference |
| url | https://doi.org/10.1186/s12944-022-01660-8 |
| work_keys_str_mv | AT mingyang associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy AT yaqinxu associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy AT chonghu associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy AT shuhuazhang associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy AT maobinkuang associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy AT yangzou associationbetweenhypertriglyceridemicwaistphenotypeandnonalcoholicfattyliverdiseaseageneralpopulationbasedstudy |