Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration
Abstract For bone defect repair, it is critical to utilize biomaterials with pro‐angiogenic properties to enhance osteogenesis. Hydroxyapatite (HA)‐based materials widely used in clinical applications have shown much potential for bone repair. However, their predominant calcium phosphate (CaP) compo...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-07-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202300224 |
| _version_ | 1797676570943422464 |
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| author | Ling Wei Zhiyun Du Chenguang Zhang Yingying Zhou Fangyu Zhu Yumin Chen Han Zhao Fengyi Zhang Pengrui Dang Yijun Wang Yanze Meng Boon Chin Heng Hongcheng Zhang Jinlin Song Wenwen Liu Qing Cai Xuliang Deng |
| author_facet | Ling Wei Zhiyun Du Chenguang Zhang Yingying Zhou Fangyu Zhu Yumin Chen Han Zhao Fengyi Zhang Pengrui Dang Yijun Wang Yanze Meng Boon Chin Heng Hongcheng Zhang Jinlin Song Wenwen Liu Qing Cai Xuliang Deng |
| author_sort | Ling Wei |
| collection | DOAJ |
| description | Abstract For bone defect repair, it is critical to utilize biomaterials with pro‐angiogenic properties to enhance osteogenesis. Hydroxyapatite (HA)‐based materials widely used in clinical applications have shown much potential for bone repair. However, their predominant calcium phosphate (CaP) composition and poor biodegradability limit their angiogenic potential and hence osteogenic efficiency of HA‐based materials. Here, a magnesium ion‐doped calcium silicate/HA composite microscaffold (Mg‐CS/HA) is fabricated to enhance angiogenesis and osteogenic efficiency for bone repair. Incorporation of CS improved the biodegradability of the Mg‐CS/HA microscaffold, which could simultaneously release Si and Mg bioactive ions during the early stage of implantation, synergistically enhancing angiogenesis and osteogenic efficiency. In co‐culture systems, the synergistic effects of Si and Mg ions promote the “osteogenesis‐angiogenesis coupling effect.” In vivo, the Mg‐CS/HA microscaffold could significantly promote reconstruction of the vascular network and bone regeneration. This study thus provides a new strategy for coordinated release of bioactive ions to achieve synergistic effects on vascularized bone regeneration by HA‐based bone implant materials. |
| first_indexed | 2024-03-11T22:30:08Z |
| format | Article |
| id | doaj.art-a7c3b57a99ff434f9db061e1ef16b7d2 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-11T22:30:08Z |
| publishDate | 2023-07-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-a7c3b57a99ff434f9db061e1ef16b7d22023-09-23T06:52:43ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-07-011020n/an/a10.1002/admi.202300224Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone RegenerationLing Wei0Zhiyun Du1Chenguang Zhang2Yingying Zhou3Fangyu Zhu4Yumin Chen5Han Zhao6Fengyi Zhang7Pengrui Dang8Yijun Wang9Yanze Meng10Boon Chin Heng11Hongcheng Zhang12Jinlin Song13Wenwen Liu14Qing Cai15Xuliang Deng16Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaState Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 ChinaHospital of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaDepartment of Orthopedics The Second Xiangya Hospital Central South University Changsha 410011 ChinaLiaoning Provincial Key Laboratory of Oral Diseases The VIP Department School and Hospital of Stomatology China Medical University Shenyang 110002 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaCentral Laboratory Peking University School and Hospital of Stomatology Beijing 100081 ChinaFoshan (Southern China) Institute for New Materials Foshan 528200 ChinaCollege of Stomatology Chongqing Medical University Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing 401147 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaState Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaAbstract For bone defect repair, it is critical to utilize biomaterials with pro‐angiogenic properties to enhance osteogenesis. Hydroxyapatite (HA)‐based materials widely used in clinical applications have shown much potential for bone repair. However, their predominant calcium phosphate (CaP) composition and poor biodegradability limit their angiogenic potential and hence osteogenic efficiency of HA‐based materials. Here, a magnesium ion‐doped calcium silicate/HA composite microscaffold (Mg‐CS/HA) is fabricated to enhance angiogenesis and osteogenic efficiency for bone repair. Incorporation of CS improved the biodegradability of the Mg‐CS/HA microscaffold, which could simultaneously release Si and Mg bioactive ions during the early stage of implantation, synergistically enhancing angiogenesis and osteogenic efficiency. In co‐culture systems, the synergistic effects of Si and Mg ions promote the “osteogenesis‐angiogenesis coupling effect.” In vivo, the Mg‐CS/HA microscaffold could significantly promote reconstruction of the vascular network and bone regeneration. This study thus provides a new strategy for coordinated release of bioactive ions to achieve synergistic effects on vascularized bone regeneration by HA‐based bone implant materials.https://doi.org/10.1002/admi.202300224angiogenesisbone regenerationcrosstalkhydroxyapatiteosteogenesis‐angiogenesis coupling |
| spellingShingle | Ling Wei Zhiyun Du Chenguang Zhang Yingying Zhou Fangyu Zhu Yumin Chen Han Zhao Fengyi Zhang Pengrui Dang Yijun Wang Yanze Meng Boon Chin Heng Hongcheng Zhang Jinlin Song Wenwen Liu Qing Cai Xuliang Deng Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration Advanced Materials Interfaces angiogenesis bone regeneration crosstalk hydroxyapatite osteogenesis‐angiogenesis coupling |
| title | Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration |
| title_full | Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration |
| title_fullStr | Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration |
| title_full_unstemmed | Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration |
| title_short | Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration |
| title_sort | mg cs ha microscaffolds display excellent biodegradability and controlled release of si and mg bioactive ions to synergistically promote vascularized bone regeneration |
| topic | angiogenesis bone regeneration crosstalk hydroxyapatite osteogenesis‐angiogenesis coupling |
| url | https://doi.org/10.1002/admi.202300224 |
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