Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review
Background: Cervical stump cancer is a rare disease, which is subsequent to a previous subtotal hysterectomy. Among patients who underwent a subtotal hysterectomy, approximately 1%–3% develop cervical stump cancer which represents 3%–9% of all the cervical cancers. Methods: After acquiring consent f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2024-01-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101011 |
| _version_ | 1797338499414753280 |
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| author | Jia Wang Xi Zeng Lin Min Lin Li |
| author_facet | Jia Wang Xi Zeng Lin Min Lin Li |
| author_sort | Jia Wang |
| collection | DOAJ |
| description | Background: Cervical stump cancer is a rare disease, which is subsequent to a previous subtotal hysterectomy. Among patients who underwent a subtotal hysterectomy, approximately 1%–3% develop cervical stump cancer which represents 3%–9% of all the cervical cancers. Methods: After acquiring consent from our ethics committee, we recruited the subjects and reviewed the patients’ data of those who were admitted to our hospital from January 2010 to December 2022. Written informed consent from all the study participants was acquired, and all materials complied with the Declaration of Helsinki and ethical standards. The patients’ data records, including clinical characteristics, treatment methods, human papillomavirus (HPV) infection conditions before the operation, complications of the treatment and follow-up status were analyzed. The HPV infection status was detected by Tellgen systems (Tellgen Corporation, Shanghai, China). SPSS software (Version 22.0, IBM Company, Armonk, NY, USA) was used for data analysis. Data is shown as mean ± standard deviation. A two-side p value < 0.05 was considered to be significant. Results: There were 127 cases with cervical stump cancer treated in our hospital during this period. The interval time between subtotal hysterectomy and stump cancer was 130.7 months. Vaginal bleeding, postcoital bleeding and pelvic pain were the main symptom. Seventy-two cases were squamous cancer and adenocarcinoma occurred in 39 cases. All patients received surgery or concurrent chemoradiotherapy. One hundred and ten cases were included in the follow-up. The median observation time was 65 months. Vaginal bleeding, gastrointestinal symptoms and vaginal contracture were the most common complications. The median observation time was 65 months and the 5-year disease-free rate for all patients was 51.8% with the 5-year overall survival for all patients being 77.3%. Conclusions: Subtotal hysterectomy results in a potential to develop cervical stump cancer. Cytological studies, cervical biopsy and endocervical curettage should be considered before a subtotal hysterectomy is performed. The patients should be well informed of the risk for retaining the cervical stump and further cervical stump cancer screening is mandatory. |
| first_indexed | 2024-03-08T09:32:08Z |
| format | Article |
| id | doaj.art-a7c6c2c03b544c3580ace1d6615a522d |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-08T09:32:08Z |
| publishDate | 2024-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-a7c6c2c03b544c3580ace1d6615a522d2024-01-31T01:12:31ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-01-015111110.31083/j.ceog5101011S0390-6663(23)02229-7Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature ReviewJia Wang0Xi Zeng1Lin Min2Lin Li3Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, ChinaBackground: Cervical stump cancer is a rare disease, which is subsequent to a previous subtotal hysterectomy. Among patients who underwent a subtotal hysterectomy, approximately 1%–3% develop cervical stump cancer which represents 3%–9% of all the cervical cancers. Methods: After acquiring consent from our ethics committee, we recruited the subjects and reviewed the patients’ data of those who were admitted to our hospital from January 2010 to December 2022. Written informed consent from all the study participants was acquired, and all materials complied with the Declaration of Helsinki and ethical standards. The patients’ data records, including clinical characteristics, treatment methods, human papillomavirus (HPV) infection conditions before the operation, complications of the treatment and follow-up status were analyzed. The HPV infection status was detected by Tellgen systems (Tellgen Corporation, Shanghai, China). SPSS software (Version 22.0, IBM Company, Armonk, NY, USA) was used for data analysis. Data is shown as mean ± standard deviation. A two-side p value < 0.05 was considered to be significant. Results: There were 127 cases with cervical stump cancer treated in our hospital during this period. The interval time between subtotal hysterectomy and stump cancer was 130.7 months. Vaginal bleeding, postcoital bleeding and pelvic pain were the main symptom. Seventy-two cases were squamous cancer and adenocarcinoma occurred in 39 cases. All patients received surgery or concurrent chemoradiotherapy. One hundred and ten cases were included in the follow-up. The median observation time was 65 months. Vaginal bleeding, gastrointestinal symptoms and vaginal contracture were the most common complications. The median observation time was 65 months and the 5-year disease-free rate for all patients was 51.8% with the 5-year overall survival for all patients being 77.3%. Conclusions: Subtotal hysterectomy results in a potential to develop cervical stump cancer. Cytological studies, cervical biopsy and endocervical curettage should be considered before a subtotal hysterectomy is performed. The patients should be well informed of the risk for retaining the cervical stump and further cervical stump cancer screening is mandatory.https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101011cervical stump cancersubtotal hysterectomyretrospective analysis |
| spellingShingle | Jia Wang Xi Zeng Lin Min Lin Li Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review Clinical and Experimental Obstetrics & Gynecology cervical stump cancer subtotal hysterectomy retrospective analysis |
| title | Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review |
| title_full | Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review |
| title_fullStr | Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review |
| title_full_unstemmed | Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review |
| title_short | Cervical Stump Cancer after Subtotal Hysterectomy: A Retrospective Research of 127 Cases from China and Literature Review |
| title_sort | cervical stump cancer after subtotal hysterectomy a retrospective research of 127 cases from china and literature review |
| topic | cervical stump cancer subtotal hysterectomy retrospective analysis |
| url | https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101011 |
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