Validation of an ICH Q2 Compliant Flow Cytometry-Based Assay for the Assessment of the Inhibitory Potential of Mesenchymal Stromal Cells on T Cell Proliferation

Validation of an ICH Q2 Compliant Flow Cytometry-Based Assay for the Assessment of the Inhibitory Potential of Mesenchymal Stromal Cells on T Cell Proliferation

Mesenchymal stromal cells (MSCs) have the potential to suppress pathological activation of immune cells and have therefore been considered for the treatment of Graft-versus-Host-Disease. The clinical application of MSCs requires a process validation to ensure consistent quality. A flow cytometry-bas...

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Bibliographic Details
Main Authors: Natascha Piede, Melanie Bremm, Anne Farken, Lisa-Marie Pfeffermann, Claudia Cappel, Halvard Bonig, Theres Fingerhut, Laura Puth, Kathrin Vogelsang, Andreas Peinelt, Rolf Marschalek, Matthias Müller, Peter Bader, Zyrafete Kuçi, Selim Kuçi, Sabine Huenecke
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
mesenchymal stem/stromal cell
lymphocyte proliferation
potency assay
quality control
mixed lymphocyte reaction
graft-versus-host disease
Online Access:https://www.mdpi.com/2073-4409/12/6/850

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https://www.mdpi.com/2073-4409/12/6/850

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