Validation of an ICH Q2 Compliant Flow Cytometry-Based Assay for the Assessment of the Inhibitory Potential of Mesenchymal Stromal Cells on T Cell Proliferation
Mesenchymal stromal cells (MSCs) have the potential to suppress pathological activation of immune cells and have therefore been considered for the treatment of Graft-versus-Host-Disease. The clinical application of MSCs requires a process validation to ensure consistent quality. A flow cytometry-bas...
Main Authors: | Natascha Piede, Melanie Bremm, Anne Farken, Lisa-Marie Pfeffermann, Claudia Cappel, Halvard Bonig, Theres Fingerhut, Laura Puth, Kathrin Vogelsang, Andreas Peinelt, Rolf Marschalek, Matthias Müller, Peter Bader, Zyrafete Kuçi, Selim Kuçi, Sabine Huenecke |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-03-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/6/850 |
Similar Items
-
Expression of HLA-DR by mesenchymal stromal cells in the platelet lysate era: an obsolete release criterion for MSCs?
by: Zyrafete Kuçi, et al.
Published: (2024-01-01) -
A New Perspective for Bone Tissue Engineering: Human Mesenchymal Stromal Cells Well-Survive Cryopreservation on β-TCP Scaffold and Show Increased Ability for Osteogenic Differentiation
by: Liudmila Leppik, et al.
Published: (2022-01-01) -
Alterations of Peripheral Blood T Cell Subsets following Donor Lymphocyte Infusion in Patients after Allogeneic Stem Cell Transplantation
by: Ann-Kristin Schmaelter, et al.
Published: (2021-11-01) -
Will New Drugs Replace Transplants for Chronic Lymphocytic Leukaemia?
by: Shenmiao Yang, et al.
Published: (2021-06-01) -
The graft versus leukemia effect: donor lymphocyte infusions and cellular therapy
by: Katie Maurer, et al.
Published: (2024-03-01)