Co-Delivery of the Human NY-ESO-1 Tumor-Associated Antigen and Alpha-GalactosylCeramide by Filamentous Bacteriophages Strongly Enhances the Expansion of Tumor-Specific CD8+ T Cells

Co-Delivery of the Human NY-ESO-1 Tumor-Associated Antigen and Alpha-GalactosylCeramide by Filamentous Bacteriophages Strongly Enhances the Expansion of Tumor-Specific CD8+ T Cells

Tumor-associated antigens (TAAs) represent attractive targets in the development of anti-cancer vaccines. The filamentous bacteriophage is a safe and versatile delivery nanosystem, and recombinant bacteriophages expressing TAA-derived peptides at a high density on the viral coat proteins improve TAA...

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Bibliographic Details
Main Authors: Roberta Manco, Luciana D’Apice, Maria Trovato, Lucia Lione, Erika Salvatori, Eleonora Pinto, Mirco Compagnone, Luigi Aurisicchio, Piergiuseppe De Berardinis, Rossella Sartorius
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
filamentous bacteriophage
NY-ESO-1
iNKT
CD8+ T cell
alpha-GalactosylCeramide
vaccine
Online Access:https://www.mdpi.com/1999-4915/15/3/672

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