Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms
The upregulation of tumor necrosis factor-alpha (TNF-α) is a common event in arthritis, and the subsequent signaling cascade that leads to tissue damage has become the research focus. To explore a potential therapeutic strategy to prevent cartilage degradation, we tested the effect of ginsenoside Rg...
Main Authors: | Ching-Hou Ma, Wan-Ching Chou, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Pei-Ling Hsieh, Kun-Ling Tsai |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/10/12/1972 |
Similar Items
-
Anti-Angiogenic Properties of Ginsenoside Rg3
by: Maryam Nakhjavani, et al.
Published: (2020-10-01) -
Metabolism of 20(S)-Ginsenoside Rg2 by Rat Liver Microsomes: Bioactivation to SIRT1-Activating Metabolites
by: Li-Yuan Ma, et al.
Published: (2016-06-01) -
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis
by: Ching-Hou Ma, et al.
Published: (2018-05-01) -
Experimental Evidence for the Anti-Metastatic Action of Ginsenoside Rg3: A Systematic Review
by: Hyeon-Muk Oh, et al.
Published: (2022-08-01) -
Ginsenosides Rg1 and Rg2 Activate Autophagy and Attenuate Oxidative Stress in Neuroblastoma Cells Overexpressing Aβ(1-42)
by: Ziqi Liu, et al.
Published: (2024-03-01)