Innate and Adaptive Immune Responses to Herpes Simplex Virus
Immune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. The innate response to HSV involves the induction of type I IFN, whose role in protection against disease is well characterized in vitro and in vivo....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-11-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/1/3/979/ |
| _version_ | 1811295119479930880 |
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| author | Karen L. Mossman Tracy Chew Kathryne E. Taylor |
| author_facet | Karen L. Mossman Tracy Chew Kathryne E. Taylor |
| author_sort | Karen L. Mossman |
| collection | DOAJ |
| description | Immune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. The innate response to HSV involves the induction of type I IFN, whose role in protection against disease is well characterized in vitro and in vivo. Cell types such as NK cells and pDCs contribute to innate anti-HSV responses in vivo. Finally, the adaptive response includes both humoral and cellular components that play important roles in antiviral control and latency. This review summarizes the innate and adaptive effectors that contribute to susceptibility, immune control and pathogenesis of HSV, and highlights the delicate interplay between these two important arms of immunity. |
| first_indexed | 2024-04-13T05:28:23Z |
| format | Article |
| id | doaj.art-a7ca5bd86ecc4306a667dabbd709a0a2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T05:28:23Z |
| publishDate | 2009-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a7ca5bd86ecc4306a667dabbd709a0a22022-12-22T03:00:31ZengMDPI AGViruses1999-49152009-11-0113979100210.3390/v1030979Innate and Adaptive Immune Responses to Herpes Simplex VirusKaren L. MossmanTracy ChewKathryne E. TaylorImmune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. The innate response to HSV involves the induction of type I IFN, whose role in protection against disease is well characterized in vitro and in vivo. Cell types such as NK cells and pDCs contribute to innate anti-HSV responses in vivo. Finally, the adaptive response includes both humoral and cellular components that play important roles in antiviral control and latency. This review summarizes the innate and adaptive effectors that contribute to susceptibility, immune control and pathogenesis of HSV, and highlights the delicate interplay between these two important arms of immunity.http://www.mdpi.com/1999-4915/1/3/979/Herpes Simplex virus (HSV)innate immunityantiviral signalingtype I interferon (IFN)Natural killer (NK) cellsplasmacytoid dendritic cells (pDCs)adaptive immunity |
| spellingShingle | Karen L. Mossman Tracy Chew Kathryne E. Taylor Innate and Adaptive Immune Responses to Herpes Simplex Virus Viruses Herpes Simplex virus (HSV) innate immunity antiviral signaling type I interferon (IFN) Natural killer (NK) cells plasmacytoid dendritic cells (pDCs) adaptive immunity |
| title | Innate and Adaptive Immune Responses to Herpes Simplex Virus |
| title_full | Innate and Adaptive Immune Responses to Herpes Simplex Virus |
| title_fullStr | Innate and Adaptive Immune Responses to Herpes Simplex Virus |
| title_full_unstemmed | Innate and Adaptive Immune Responses to Herpes Simplex Virus |
| title_short | Innate and Adaptive Immune Responses to Herpes Simplex Virus |
| title_sort | innate and adaptive immune responses to herpes simplex virus |
| topic | Herpes Simplex virus (HSV) innate immunity antiviral signaling type I interferon (IFN) Natural killer (NK) cells plasmacytoid dendritic cells (pDCs) adaptive immunity |
| url | http://www.mdpi.com/1999-4915/1/3/979/ |
| work_keys_str_mv | AT karenlmossman innateandadaptiveimmuneresponsestoherpessimplexvirus AT tracychew innateandadaptiveimmuneresponsestoherpessimplexvirus AT kathryneetaylor innateandadaptiveimmuneresponsestoherpessimplexvirus |