Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis
<strong><em>Objective(s):</em></strong>The aim of this study was to determine whether technetium (<sup>99m</sup>Tc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-01-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | http://aojnmb.mums.ac.ir/article_14241_cd3ba2ff543b3771abc88af8f181d5aa.pdf |
| _version_ | 1818720202097950720 |
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| author | Fadime Demir |
| author_facet | Fadime Demir |
| author_sort | Fadime Demir |
| collection | DOAJ |
| description | <strong><em>Objective(s):</em></strong>The aim of this study was to determine whether technetium (<sup>99m</sup>Tc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its relevancy.
<strong><em>Methods: </em></strong>A total of 69 patients, who were followed up (>3 months) in our hospital for thyrotoxicosis within 2015-2019 were enrolled in the study. Out of these 69 subjects, 39 patients had been diagnosed with Graves disease, and 30 of them had subacute thyroiditis. Biochemical parameters, thyroid scintigraphy, and <sup>99m</sup>Tc uptake test results were evaluated.
<strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em><sup>99m</sup>Tc uptake was significantly higher in the patients with Graves disease than in the patients with subacute thyroiditis (P<0.001). Based on the ROC analysis the <sup>99m</sup>Tc uptake cutoff value of 1.55% had an accuracy of 92.9%, with the sensitivity and specificity of 92% and 87%, respectively.
<strong><em>Conclusion:</em></strong>In conclusion, the results of our study suggested that <sup>99m</sup>Tc uptake test could be used in the differential diagnosis of Graves disease and subacute thyroiditis. The cutoff value of 1.55% for <sup>99m</sup>Tc uptake test may guide in establishing a differential diagnosis between the two diseases. |
| first_indexed | 2024-12-17T20:19:05Z |
| format | Article |
| id | doaj.art-a7cbef531c114ad7a914eead839006d6 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-17T20:19:05Z |
| publishDate | 2020-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-a7cbef531c114ad7a914eead839006d62022-12-21T21:34:00ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262020-01-0181545710.22038/aojnmb.2019.1424114241Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditisFadime Demir0Department of Nuclear Medicine, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey<strong><em>Objective(s):</em></strong>The aim of this study was to determine whether technetium (<sup>99m</sup>Tc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its relevancy. <strong><em>Methods: </em></strong>A total of 69 patients, who were followed up (>3 months) in our hospital for thyrotoxicosis within 2015-2019 were enrolled in the study. Out of these 69 subjects, 39 patients had been diagnosed with Graves disease, and 30 of them had subacute thyroiditis. Biochemical parameters, thyroid scintigraphy, and <sup>99m</sup>Tc uptake test results were evaluated. <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em><sup>99m</sup>Tc uptake was significantly higher in the patients with Graves disease than in the patients with subacute thyroiditis (P<0.001). Based on the ROC analysis the <sup>99m</sup>Tc uptake cutoff value of 1.55% had an accuracy of 92.9%, with the sensitivity and specificity of 92% and 87%, respectively. <strong><em>Conclusion:</em></strong>In conclusion, the results of our study suggested that <sup>99m</sup>Tc uptake test could be used in the differential diagnosis of Graves disease and subacute thyroiditis. The cutoff value of 1.55% for <sup>99m</sup>Tc uptake test may guide in establishing a differential diagnosis between the two diseases.http://aojnmb.mums.ac.ir/article_14241_cd3ba2ff543b3771abc88af8f181d5aa.pdftechnetium uptakegravessubacute thyroiditis |
| spellingShingle | Fadime Demir Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis Asia Oceania Journal of Nuclear Medicine and Biology technetium uptake graves subacute thyroiditis |
| title | Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis |
| title_full | Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis |
| title_fullStr | Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis |
| title_full_unstemmed | Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis |
| title_short | Cut off value of technetium uptake in the differential diagnosis of Graves, disease and subacute thyroiditis |
| title_sort | cut off value of technetium uptake in the differential diagnosis of graves disease and subacute thyroiditis |
| topic | technetium uptake graves subacute thyroiditis |
| url | http://aojnmb.mums.ac.ir/article_14241_cd3ba2ff543b3771abc88af8f181d5aa.pdf |
| work_keys_str_mv | AT fadimedemir cutoffvalueoftechnetiumuptakeinthedifferentialdiagnosisofgravesdiseaseandsubacutethyroiditis |