A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model
Objectives: This study aimed to investigate the protective effect and antioxidant activity of an herbal product that made from multiple plants in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. Materials and methods: Twenty-four rats were divided into four different groups na...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2017-10-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | http://pagepressjournals.org/index.php/aiua/article/view/6825 |
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| author | Eyup Veli Kucuk Ahmet Bindayi Meral Mese Funda Gulcu Bulmus Ergun Parmaksiz Ali Cihangir Cetinel Zerrin Bicik Bahcebasi Kemal Sarica |
| author_facet | Eyup Veli Kucuk Ahmet Bindayi Meral Mese Funda Gulcu Bulmus Ergun Parmaksiz Ali Cihangir Cetinel Zerrin Bicik Bahcebasi Kemal Sarica |
| author_sort | Eyup Veli Kucuk |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate the protective effect and antioxidant activity of an herbal product that made from multiple plants in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. Materials and methods: Twenty-four rats were divided into four different groups namely: Group 1 - control healthy animals without any specific medication, Group 2 - Herbal product only 5 mg/kg, Group 3 - cisplatin only and Group 4 - Herbal product 5 mg/kg + cisplatin. Results: Evaluation of our findings demonstrated a significant (p = 0.017) reduction in Catalase activities and a significant increase (p = 0.001) in renal tissue Malondialdehyde levels in cisplatin- treated rats when compared with the control group. Also, Glutathion and Glutathione peroxidase content revealed significant (p = 0.031) reduction in renal tissues of cisplatintreated rats compared with the control group. Pre-treatment of rats with the herbal product ameliorated these cisplatininduced changes of the antioxidant enzymes. No statistically significant changes were demonstrated in Superoxide dismutase activities in the tissue specimens of any group. Conclusions: This potent antioxidant herbal medicine was found to have potential antioxidant activity, which may in turn to be effective in the protection of kidney tissue resulting from cisplatin application. Therefore, much attention should be given to the possible role of natural dietary antioxidants for protecting the kidney. |
| first_indexed | 2024-04-13T03:38:19Z |
| format | Article |
| id | doaj.art-a7cc0243f5fa44db86cf52a013662f88 |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-04-13T03:38:19Z |
| publishDate | 2017-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-a7cc0243f5fa44db86cf52a013662f882022-12-22T03:04:16ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972017-10-0189319219610.4081/aiua.2017.3.1925413A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat modelEyup Veli Kucuk0Ahmet Bindayi1Meral Mese2Funda Gulcu Bulmus3Ergun Parmaksiz4Ali Cihangir Cetinel5Zerrin Bicik Bahcebasi6Kemal Sarica7Umraniye Training and Research Hospital Urology Clinic, IstanbulBahcesehir University Department of Urology, IstanbulDr. Lütfi Kirdar Training and Research Hospital Nephrology Clinic, IstanbulDr. Lütfi Kirdar Training and Research Hospital Nephrology Clinic, IstanbulDr. Lütfi Kirdar Training and Research Hospital Nephrology Clinic, IstanbulDr. Lütfi Kirdar Training and Research Hospital Urology Clinic, IstanbulDr. Lütfi Kirdar Training and Research Hospital Nephrology Clinic, IstanbulDr. Lütfi Kirdar Training and Research Hospital Urology Clinic, IstanbulObjectives: This study aimed to investigate the protective effect and antioxidant activity of an herbal product that made from multiple plants in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. Materials and methods: Twenty-four rats were divided into four different groups namely: Group 1 - control healthy animals without any specific medication, Group 2 - Herbal product only 5 mg/kg, Group 3 - cisplatin only and Group 4 - Herbal product 5 mg/kg + cisplatin. Results: Evaluation of our findings demonstrated a significant (p = 0.017) reduction in Catalase activities and a significant increase (p = 0.001) in renal tissue Malondialdehyde levels in cisplatin- treated rats when compared with the control group. Also, Glutathion and Glutathione peroxidase content revealed significant (p = 0.031) reduction in renal tissues of cisplatintreated rats compared with the control group. Pre-treatment of rats with the herbal product ameliorated these cisplatininduced changes of the antioxidant enzymes. No statistically significant changes were demonstrated in Superoxide dismutase activities in the tissue specimens of any group. Conclusions: This potent antioxidant herbal medicine was found to have potential antioxidant activity, which may in turn to be effective in the protection of kidney tissue resulting from cisplatin application. Therefore, much attention should be given to the possible role of natural dietary antioxidants for protecting the kidney.http://pagepressjournals.org/index.php/aiua/article/view/6825Animal modelAntioxidantsCisplatinHerbal medicineNephrotoxicity |
| spellingShingle | Eyup Veli Kucuk Ahmet Bindayi Meral Mese Funda Gulcu Bulmus Ergun Parmaksiz Ali Cihangir Cetinel Zerrin Bicik Bahcebasi Kemal Sarica A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model Archivio Italiano di Urologia e Andrologia Animal model Antioxidants Cisplatin Herbal medicine Nephrotoxicity |
| title | A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model |
| title_full | A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model |
| title_fullStr | A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model |
| title_full_unstemmed | A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model |
| title_short | A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model |
| title_sort | randomized study to assess the efficacy of herbal product to prevent cisplatin induced nephrotoxicity in a rat model |
| topic | Animal model Antioxidants Cisplatin Herbal medicine Nephrotoxicity |
| url | http://pagepressjournals.org/index.php/aiua/article/view/6825 |
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