DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy
<p>Abstract</p> <p>Background</p> <p>More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most common...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
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| Series: | Trials |
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| Online Access: | http://www.trialsjournal.com/content/13/1/155 |
| _version_ | 1818140358033276928 |
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| author | Rothenhoefer Simone Herrle Florian Herold Alexander Joos Andreas Bussen Dieter Kieser Meinhard Schiller Petra Klose Christina Seiler Christoph M Kienle Peter Post Stefan |
| author_facet | Rothenhoefer Simone Herrle Florian Herold Alexander Joos Andreas Bussen Dieter Kieser Meinhard Schiller Petra Klose Christina Seiler Christoph M Kienle Peter Post Stefan |
| author_sort | Rothenhoefer Simone |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most commonly used abdominal procedure. Recurrences seem more common after perineal compared to abdominal techniques, but the latter may carry a higher risk of peri- and postoperative morbidity and mortality.</p> <p>Methods/Design</p> <p>DeloRes is a randomized, controlled, observer-blinded multicenter trial with two parallel groups. Patients with a full-thickness rectal prolapse (third degree prolapse), considered eligible for both operative methods are included. The primary outcome is time to recurrence of full-thickness rectal prolapse during the 24 months following primary surgery. Secondary endpoints are time to and incidence of recurrence of full-thickness rectal prolapse during the 5-year follow-up, duration of surgery, morbidity, hospital stay, quality of life, constipation, and fecal incontinence. A meta-analysis was done on the basis of the available data on recurrence rates from 17 publications comprising 1,140 patients. Based on the results of a meta-analysis it is assumed that the recurrence rate after 2 years is 20% for Delorme’s procedure and 5% for resection rectopexy. Considering a rate of lost to follow-up without recurrence of 30% a total of 130 patients (2 x 65 patients) was calculated as an adequate sample size to assure a power of 80% for the confirmatory analysis.</p> <p>Discussion</p> <p>The DeloRes Trial will clarify which procedure results in a smaller recurrence rate but also give information on how morbidity and functional results compare.</p> <p>Trial registration</p> <p>German Clinical Trial Number DRKS00000482</p> |
| first_indexed | 2024-12-11T10:42:43Z |
| format | Article |
| id | doaj.art-a7ce42033c3b43f1930011ba6d5bed6b |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-11T10:42:43Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-a7ce42033c3b43f1930011ba6d5bed6b2022-12-22T01:10:33ZengBMCTrials1745-62152012-08-0113115510.1186/1745-6215-13-155DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexyRothenhoefer SimoneHerrle FlorianHerold AlexanderJoos AndreasBussen DieterKieser MeinhardSchiller PetraKlose ChristinaSeiler Christoph MKienle PeterPost Stefan<p>Abstract</p> <p>Background</p> <p>More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most commonly used abdominal procedure. Recurrences seem more common after perineal compared to abdominal techniques, but the latter may carry a higher risk of peri- and postoperative morbidity and mortality.</p> <p>Methods/Design</p> <p>DeloRes is a randomized, controlled, observer-blinded multicenter trial with two parallel groups. Patients with a full-thickness rectal prolapse (third degree prolapse), considered eligible for both operative methods are included. The primary outcome is time to recurrence of full-thickness rectal prolapse during the 24 months following primary surgery. Secondary endpoints are time to and incidence of recurrence of full-thickness rectal prolapse during the 5-year follow-up, duration of surgery, morbidity, hospital stay, quality of life, constipation, and fecal incontinence. A meta-analysis was done on the basis of the available data on recurrence rates from 17 publications comprising 1,140 patients. Based on the results of a meta-analysis it is assumed that the recurrence rate after 2 years is 20% for Delorme’s procedure and 5% for resection rectopexy. Considering a rate of lost to follow-up without recurrence of 30% a total of 130 patients (2 x 65 patients) was calculated as an adequate sample size to assure a power of 80% for the confirmatory analysis.</p> <p>Discussion</p> <p>The DeloRes Trial will clarify which procedure results in a smaller recurrence rate but also give information on how morbidity and functional results compare.</p> <p>Trial registration</p> <p>German Clinical Trial Number DRKS00000482</p>http://www.trialsjournal.com/content/13/1/155Rectal prolapseSurgeryDelorme’s procedureResection rectopexyRecurrence |
| spellingShingle | Rothenhoefer Simone Herrle Florian Herold Alexander Joos Andreas Bussen Dieter Kieser Meinhard Schiller Petra Klose Christina Seiler Christoph M Kienle Peter Post Stefan DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy Trials Rectal prolapse Surgery Delorme’s procedure Resection rectopexy Recurrence |
| title | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
| title_full | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
| title_fullStr | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
| title_full_unstemmed | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
| title_short | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
| title_sort | delores trial study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse delorme s procedure versus resection rectopexy |
| topic | Rectal prolapse Surgery Delorme’s procedure Resection rectopexy Recurrence |
| url | http://www.trialsjournal.com/content/13/1/155 |
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