Understanding the roles of gingival beta-defensins
Gingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2012-02-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://www.journaloforalmicrobiology.net/index.php/jom/article/view/15127/20121 |
| _version_ | 1818300738174976000 |
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| author | Ulvi Kahraman Gursoy Eija Könönen |
| author_facet | Ulvi Kahraman Gursoy Eija Könönen |
| author_sort | Ulvi Kahraman Gursoy |
| collection | DOAJ |
| description | Gingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved in the initiation and progression, as well as restriction of periodontal tissue destruction, by acting as antimicrobial, chemotactic, and anti-inflammatory agents. In this article, we review the common knowledge about β-defensins, coming from in vivo and in vitro monolayer studies, and present new aspects, based on the experience on three-dimensional organotypic culture models, to the important role of gingival β-defensins in homeostasis of the periodontium. |
| first_indexed | 2024-12-13T05:11:53Z |
| format | Article |
| id | doaj.art-a7d0f3b067684ec2b357961804f1a0b4 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-13T05:11:53Z |
| publishDate | 2012-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-a7d0f3b067684ec2b357961804f1a0b42022-12-21T23:58:31ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972012-02-014011010.3402/jom.v4i0.15127Understanding the roles of gingival beta-defensinsUlvi Kahraman GursoyEija KönönenGingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved in the initiation and progression, as well as restriction of periodontal tissue destruction, by acting as antimicrobial, chemotactic, and anti-inflammatory agents. In this article, we review the common knowledge about β-defensins, coming from in vivo and in vitro monolayer studies, and present new aspects, based on the experience on three-dimensional organotypic culture models, to the important role of gingival β-defensins in homeostasis of the periodontium.http://www.journaloforalmicrobiology.net/index.php/jom/article/view/15127/20121bacteriabeta-defensinsepitheliumperiodontium |
| spellingShingle | Ulvi Kahraman Gursoy Eija Könönen Understanding the roles of gingival beta-defensins Journal of Oral Microbiology bacteria beta-defensins epithelium periodontium |
| title | Understanding the roles of gingival beta-defensins |
| title_full | Understanding the roles of gingival beta-defensins |
| title_fullStr | Understanding the roles of gingival beta-defensins |
| title_full_unstemmed | Understanding the roles of gingival beta-defensins |
| title_short | Understanding the roles of gingival beta-defensins |
| title_sort | understanding the roles of gingival beta defensins |
| topic | bacteria beta-defensins epithelium periodontium |
| url | http://www.journaloforalmicrobiology.net/index.php/jom/article/view/15127/20121 |
| work_keys_str_mv | AT ulvikahramangursoy understandingtherolesofgingivalbetadefensins AT eijakx00f6nx00f6nen understandingtherolesofgingivalbetadefensins |