Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study
Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured i...
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| Format: | Article |
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Elsevier
2024-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S016041202300613X |
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| author | Ling-Wei Chen Sharon Ng Mya-Thway Tint Navin Michael Suresh Anand Sadananthan Yi Ying Ong Wen Lun Yuan Ze-Ying Chen Chia-Yang Chen Keith M. Godfrey Kok Hian Tan Peter D. Gluckman Yap-Seng Chong Johan G. Eriksson Fabian Yap Yung Seng Lee Marielle V. Fortier Sendhil S. Velan Shiao-Yng Chan |
| author_facet | Ling-Wei Chen Sharon Ng Mya-Thway Tint Navin Michael Suresh Anand Sadananthan Yi Ying Ong Wen Lun Yuan Ze-Ying Chen Chia-Yang Chen Keith M. Godfrey Kok Hian Tan Peter D. Gluckman Yap-Seng Chong Johan G. Eriksson Fabian Yap Yung Seng Lee Marielle V. Fortier Sendhil S. Velan Shiao-Yng Chan |
| author_sort | Ling-Wei Chen |
| collection | DOAJ |
| description | Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured in 783 cord plasma samples using ultra-performance-liquid chromatography-tandem-mass-spectrometer (UPLC-MS/MS). Outcomes included offspring anthropometry, other indicators of body composition/metabolic health, and MRI-derived abdominal adiposity (subset) at birth and 6 years of age. PFAS were modeled individually, in categories of long-chain and short-chain PFAS, and as scores of three principal components (PC) derived using PC analysis (PC1, PC2, and PC3 reflect predominant exposure patterns to “very-long-PFAS”, “long-PFAS”, and “short-PFAS”, respectively). Associations with outcomes were assessed using multivariable linear regressions, adjusted for important covariates such as maternal sociodemographic and lifestyle factors. Results: Overall, cord PFAS levels showed either no or positive associations (mostly for long-chain PFAS) with birth weight, length and head circumference. In general, PFAS were associated with higher neonatal abdominal adiposity, driven by shorter-chain PFAS. Perfluoroheptanoic acid (PFHpA) was associated with higher volumes of superficial subcutaneous adipose tissue (sSAT) (3.75 [1.13, 6.37] mL per SD increase in PFAS) and internal adipose tissue (IAT) (1.39 [0.41, 2.38] mL). Higher levels of perfluorobutanesulfonic acid (PFBS), short-chain PFAS, and PC3 were associated with higher IAT volume (β range 1.22–1.41 mL/SD, all P < 0.02), especially in girls. Higher PC3 score was additionally associated with higher sSAT (3.12 [0.45, 5.80] mL) volume. At age 6 years, most observed associations did not persist. No consistent associations were observed between PFAS and whole-body adiposity measures. Conclusions: Fetal exposure to emerging short-chain PFAS was associated with higher abdominal adiposity at birth but not at age 6 years. Further research is needed to replicate the findings and to determine if these effects may reappear beyond early childhood. Population exposure to newer PFAS and consequent health impact must be monitored. |
| first_indexed | 2024-03-08T12:31:31Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-08T12:31:31Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-a7d2592808184770b0862b11eed4fd122024-01-22T04:14:23ZengElsevierEnvironment International0160-41202024-01-01183108340Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO studyLing-Wei Chen0Sharon Ng1Mya-Thway Tint2Navin Michael3Suresh Anand Sadananthan4Yi Ying Ong5Wen Lun Yuan6Ze-Ying Chen7Chia-Yang Chen8Keith M. Godfrey9Kok Hian Tan10Peter D. Gluckman11Yap-Seng Chong12Johan G. Eriksson13Fabian Yap14Yung Seng Lee15Marielle V. Fortier16Sendhil S. Velan17Shiao-Yng Chan18Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, Taiwan; Master of Public Health Program, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, Taiwan; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USASingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004 Paris, FranceInstitute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, TaiwanInstitute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, TaiwanMRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Tremona Road, SO16 6YD Southampton, UKDuke-NUS Medical School, 8 College Road, 169857, Singapore; Department of Reproductive Medicine, KK Women’s and Children Hospital, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Liggins Institute, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New ZealandSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore; Department of General Practice and Primary Health Care, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland; Folkhälsan Research Center, Topeliusgatan 20, 00250 Helsinki, FinlandDuke-NUS Medical School, 8 College Road, 169857, Singapore; Department of Pediatric Endocrinology, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, 229899, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore; Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, 1E Kent Ridge Road, 119228, SingaporeDepartment of Diagnostic & Interventional Imaging, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, 229899, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore; Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore; Corresponding author at: Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore.Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured in 783 cord plasma samples using ultra-performance-liquid chromatography-tandem-mass-spectrometer (UPLC-MS/MS). Outcomes included offspring anthropometry, other indicators of body composition/metabolic health, and MRI-derived abdominal adiposity (subset) at birth and 6 years of age. PFAS were modeled individually, in categories of long-chain and short-chain PFAS, and as scores of three principal components (PC) derived using PC analysis (PC1, PC2, and PC3 reflect predominant exposure patterns to “very-long-PFAS”, “long-PFAS”, and “short-PFAS”, respectively). Associations with outcomes were assessed using multivariable linear regressions, adjusted for important covariates such as maternal sociodemographic and lifestyle factors. Results: Overall, cord PFAS levels showed either no or positive associations (mostly for long-chain PFAS) with birth weight, length and head circumference. In general, PFAS were associated with higher neonatal abdominal adiposity, driven by shorter-chain PFAS. Perfluoroheptanoic acid (PFHpA) was associated with higher volumes of superficial subcutaneous adipose tissue (sSAT) (3.75 [1.13, 6.37] mL per SD increase in PFAS) and internal adipose tissue (IAT) (1.39 [0.41, 2.38] mL). Higher levels of perfluorobutanesulfonic acid (PFBS), short-chain PFAS, and PC3 were associated with higher IAT volume (β range 1.22–1.41 mL/SD, all P < 0.02), especially in girls. Higher PC3 score was additionally associated with higher sSAT (3.12 [0.45, 5.80] mL) volume. At age 6 years, most observed associations did not persist. No consistent associations were observed between PFAS and whole-body adiposity measures. Conclusions: Fetal exposure to emerging short-chain PFAS was associated with higher abdominal adiposity at birth but not at age 6 years. Further research is needed to replicate the findings and to determine if these effects may reappear beyond early childhood. Population exposure to newer PFAS and consequent health impact must be monitored.http://www.sciencedirect.com/science/article/pii/S016041202300613XPrenatal exposurePer- and polyfluoroalkyl substancesPFASBirth sizeOffspring adiposityAbdominal adiposity |
| spellingShingle | Ling-Wei Chen Sharon Ng Mya-Thway Tint Navin Michael Suresh Anand Sadananthan Yi Ying Ong Wen Lun Yuan Ze-Ying Chen Chia-Yang Chen Keith M. Godfrey Kok Hian Tan Peter D. Gluckman Yap-Seng Chong Johan G. Eriksson Fabian Yap Yung Seng Lee Marielle V. Fortier Sendhil S. Velan Shiao-Yng Chan Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study Environment International Prenatal exposure Per- and polyfluoroalkyl substances PFAS Birth size Offspring adiposity Abdominal adiposity |
| title | Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study |
| title_full | Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study |
| title_fullStr | Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study |
| title_full_unstemmed | Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study |
| title_short | Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study |
| title_sort | associations of cord plasma per and polyfluoroakyl substances pfas with neonatal and child body composition and adiposity the gusto study |
| topic | Prenatal exposure Per- and polyfluoroalkyl substances PFAS Birth size Offspring adiposity Abdominal adiposity |
| url | http://www.sciencedirect.com/science/article/pii/S016041202300613X |
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