Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo

Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo

Abstract Background Osteosarcoma is the third most common cancer in adolescence and the first common primary malignant tumor of bone. The long-term prognosis of osteosarcoma still remains unsatisfactory in the past decades. Therefore, development of novel therapeutic agents which are effective to os...

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Bibliographic Details
Main Authors: Minchao Lv, Qingxin Xu, Bei Zhang, Zhiqiang Yang, Jun Xie, Jinku Guo, Feixiong He, Wei Wang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Cancer Cell International
Subjects:
Imperatorin
Osteosarcoma
PTEN-PI3K-AKT-mTOR/p21 pathway
Cell cycle
Autophagy
Online Access:https://doi.org/10.1186/s12935-021-02397-7

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