Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast
After <i>Saccharomyces cerevisiae</i> cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/13/4717 |
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| author | Karamat Mohammad Jennifer Anne Baratang Junio Tala Tafakori Emmanuel Orfanos Vladimir I. Titorenko |
| author_facet | Karamat Mohammad Jennifer Anne Baratang Junio Tala Tafakori Emmanuel Orfanos Vladimir I. Titorenko |
| author_sort | Karamat Mohammad |
| collection | DOAJ |
| description | After <i>Saccharomyces cerevisiae</i> cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discussed here. We also describe various hallmarks of quiescent and non-quiescent yeast cells. A complex aging-associated program underlies cellular quiescence in budding yeast. This quiescence program includes a cascade of consecutive cellular events orchestrated by an intricate signaling network. We examine here how caloric restriction, a low-calorie diet that extends lifespan and healthspan in yeast and other eukaryotes, influences the cellular quiescence program in <i>S. cerevisiae</i>. One of the main objectives of this review is to stimulate an exploration of the mechanisms that link cellular quiescence to chronological aging of budding yeast. Yeast chronological aging is defined by the length of time during which a yeast cell remains viable after its growth and division are arrested, and it becomes quiescent. We propose a hypothesis on how caloric restriction can slow chronological aging of <i>S. cerevisiae</i> by altering the chronology and properties of quiescent cells. Our hypothesis posits that caloric restriction delays yeast chronological aging by targeting four different processes within quiescent cells. |
| first_indexed | 2024-03-10T18:44:45Z |
| format | Article |
| id | doaj.art-a7d4616168b74ebf9d9fc35ae81f2ff5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:44:45Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a7d4616168b74ebf9d9fc35ae81f2ff52023-11-20T05:37:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012113471710.3390/ijms21134717Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding YeastKaramat Mohammad0Jennifer Anne Baratang Junio1Tala Tafakori2Emmanuel Orfanos3Vladimir I. Titorenko4Department of Biology, Concordia University, Montreal, QC H4B 1R6, CanadaDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, CanadaDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, CanadaDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, CanadaDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, CanadaAfter <i>Saccharomyces cerevisiae</i> cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discussed here. We also describe various hallmarks of quiescent and non-quiescent yeast cells. A complex aging-associated program underlies cellular quiescence in budding yeast. This quiescence program includes a cascade of consecutive cellular events orchestrated by an intricate signaling network. We examine here how caloric restriction, a low-calorie diet that extends lifespan and healthspan in yeast and other eukaryotes, influences the cellular quiescence program in <i>S. cerevisiae</i>. One of the main objectives of this review is to stimulate an exploration of the mechanisms that link cellular quiescence to chronological aging of budding yeast. Yeast chronological aging is defined by the length of time during which a yeast cell remains viable after its growth and division are arrested, and it becomes quiescent. We propose a hypothesis on how caloric restriction can slow chronological aging of <i>S. cerevisiae</i> by altering the chronology and properties of quiescent cells. Our hypothesis posits that caloric restriction delays yeast chronological aging by targeting four different processes within quiescent cells.https://www.mdpi.com/1422-0067/21/13/4717yeastcellular quiescencecellular agingcell cycleproperties of quiescent yeastquiescence entry |
| spellingShingle | Karamat Mohammad Jennifer Anne Baratang Junio Tala Tafakori Emmanuel Orfanos Vladimir I. Titorenko Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast International Journal of Molecular Sciences yeast cellular quiescence cellular aging cell cycle properties of quiescent yeast quiescence entry |
| title | Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast |
| title_full | Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast |
| title_fullStr | Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast |
| title_full_unstemmed | Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast |
| title_short | Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast |
| title_sort | mechanisms that link chronological aging to cellular quiescence in budding yeast |
| topic | yeast cellular quiescence cellular aging cell cycle properties of quiescent yeast quiescence entry |
| url | https://www.mdpi.com/1422-0067/21/13/4717 |
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