Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals
Abstract Recording electrophysiological information such as brain neural signals is of great importance in health monitoring and disease diagnosis. However, foreign body response and performance loss over time are major challenges stemming from the chemomechanical mismatch between sensors and tissue...
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202201059 |
| _version_ | 1828832205384712192 |
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| author | Quanduo Liang Xiangjiao Xia Xiguang Sun Dehai Yu Xinrui Huang Guanghong Han Samuel M. Mugo Wei Chen Qiang Zhang |
| author_facet | Quanduo Liang Xiangjiao Xia Xiguang Sun Dehai Yu Xinrui Huang Guanghong Han Samuel M. Mugo Wei Chen Qiang Zhang |
| author_sort | Quanduo Liang |
| collection | DOAJ |
| description | Abstract Recording electrophysiological information such as brain neural signals is of great importance in health monitoring and disease diagnosis. However, foreign body response and performance loss over time are major challenges stemming from the chemomechanical mismatch between sensors and tissues. Herein, microgels are utilized as large crosslinking centers in hydrogel networks to modulate the tradeoff between modulus and fatigue resistance/stretchability for producing hydrogels that closely match chemomechanical properties of neural tissues. The hydrogels exhibit notably different characteristics compared to nanoparticles reinforced hydrogels. The hydrogels exhibit relatively low modulus, good stretchability, and outstanding fatigue resistance. It is demonstrated that the hydrogels are well suited for fashioning into wearable and implantable sensors that can obtain physiological pressure signals, record the local field potentials in rat brains, and transmit signals through the injured peripheral nerves of rats. The hydrogels exhibit good chemomechanical match to tissues, negligible foreign body response, and minimal signal attenuation over an extended time, and as such is successfully demonstrated for use as long‐term implantable sensory devices. This work facilitates a deeper understanding of biohybrid interfaces, while also advancing the technical design concepts for implantable neural probes that efficiently obtain physiological information. |
| first_indexed | 2024-12-12T16:49:22Z |
| format | Article |
| id | doaj.art-a7d7ad753a7c43cc94c42640042793df |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-12T16:49:22Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-a7d7ad753a7c43cc94c42640042793df2022-12-22T00:18:24ZengWileyAdvanced Science2198-38442022-05-01916n/an/a10.1002/advs.202201059Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural SignalsQuanduo Liang0Xiangjiao Xia1Xiguang Sun2Dehai Yu3Xinrui Huang4Guanghong Han5Samuel M. Mugo6Wei Chen7Qiang Zhang8State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaState Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaBethune First Hospital of Jilin University No. 1, Xinmin Street Changchun 130061 P. R. ChinaBethune First Hospital of Jilin University No. 1, Xinmin Street Changchun 130061 P. R. ChinaBethune First Hospital of Jilin University No. 1, Xinmin Street Changchun 130061 P. R. ChinaDepartment of Oral Geriatrics Hospital of Stomatology Jilin University Changchun 130021 P. R. ChinaDepartment of Physical Sciences MacEwan University Edmonton ABT5J4S2 CanadaState Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaState Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaAbstract Recording electrophysiological information such as brain neural signals is of great importance in health monitoring and disease diagnosis. However, foreign body response and performance loss over time are major challenges stemming from the chemomechanical mismatch between sensors and tissues. Herein, microgels are utilized as large crosslinking centers in hydrogel networks to modulate the tradeoff between modulus and fatigue resistance/stretchability for producing hydrogels that closely match chemomechanical properties of neural tissues. The hydrogels exhibit notably different characteristics compared to nanoparticles reinforced hydrogels. The hydrogels exhibit relatively low modulus, good stretchability, and outstanding fatigue resistance. It is demonstrated that the hydrogels are well suited for fashioning into wearable and implantable sensors that can obtain physiological pressure signals, record the local field potentials in rat brains, and transmit signals through the injured peripheral nerves of rats. The hydrogels exhibit good chemomechanical match to tissues, negligible foreign body response, and minimal signal attenuation over an extended time, and as such is successfully demonstrated for use as long‐term implantable sensory devices. This work facilitates a deeper understanding of biohybrid interfaces, while also advancing the technical design concepts for implantable neural probes that efficiently obtain physiological information.https://doi.org/10.1002/advs.202201059brain–machine interfacehydrogelsimplantable sensorsmicrogelswearable sensors |
| spellingShingle | Quanduo Liang Xiangjiao Xia Xiguang Sun Dehai Yu Xinrui Huang Guanghong Han Samuel M. Mugo Wei Chen Qiang Zhang Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals Advanced Science brain–machine interface hydrogels implantable sensors microgels wearable sensors |
| title | Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals |
| title_full | Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals |
| title_fullStr | Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals |
| title_full_unstemmed | Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals |
| title_short | Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals |
| title_sort | highly stretchable hydrogels as wearable and implantable sensors for recording physiological and brain neural signals |
| topic | brain–machine interface hydrogels implantable sensors microgels wearable sensors |
| url | https://doi.org/10.1002/advs.202201059 |
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