Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers
Objective: The present study is devoted to the study of brain activation using fMRI in patients with depression (after acute coronary syndrome and somatically healthy) and in healthy volunteers. Method: The study enrolled a total of 51 patients: 11 with depression after acute coronary syndrome,...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-12-01
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| Series: | Iranian Journal of Psychiatry |
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| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/3624 |
| _version_ | 1797359848668528640 |
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| author | Alena Beliaevskaia Petelin Dmitry Sergeevich Akhapkin Roman Vitalievich Volel Beatrice Albertovna Ternovoy Sergey Konstantinovich |
| author_facet | Alena Beliaevskaia Petelin Dmitry Sergeevich Akhapkin Roman Vitalievich Volel Beatrice Albertovna Ternovoy Sergey Konstantinovich |
| author_sort | Alena Beliaevskaia |
| collection | DOAJ |
| description |
Objective: The present study is devoted to the study of brain activation using fMRI in patients with depression (after acute coronary syndrome and somatically healthy) and in healthy volunteers.
Method: The study enrolled a total of 51 patients: 11 with depression after acute coronary syndrome, 16 with primary depressive episode and recurrent depression without prior coronary event, and 24 with ACS without depression. The groups were matched by sex and age. The emotional information processing was evaluated with the Pennsylvania Test of Emotion Recognition. All patients underwent fMRI at the time of this test. The data processing was performed with SPM12 and xjView applications.
Results: During the processing of emotional information in the depressed patients after ACS, specific activation zones in the frontal cortex (P < 0.001), right fusiform gyrus (P < 0.001), and right insular lobe were identified (P = 0.017). In the patients with primary depressive episode and recurrent depression without ACS, certain zones of activation were identified in frontal cortex (P < 0.001; 0.001), left fusiform gyrus (P < 0.001), occipital cortex (P < 0.001). In the patients who had ACS, without depression, some zones of activation were specified in the right middle occipital gyrus (P < 0.001), the right superior frontal gyrus (P = 0.088), and the putamen projection on the right (P < 0.001) and on the left (P = 0.009), as well as the left insular lobe (P = 0.015).
Conclusion: The pathogenesis of depression is significantly associated with the peculiarities of processing emotionally significant information, regardless of the conditions under which it develops.
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| first_indexed | 2024-03-08T15:30:43Z |
| format | Article |
| id | doaj.art-a7d7c76faf454d52911fd6a46ab36995 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-03-08T15:30:43Z |
| publishDate | 2023-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-a7d7c76faf454d52911fd6a46ab369952024-01-10T06:08:42ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152023-12-0119110.18502/ijps.v19i1.14335Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy VolunteersAlena Beliaevskaia0Petelin Dmitry Sergeevich1Akhapkin Roman Vitalievich2Volel Beatrice Albertovna3Ternovoy Sergey Konstantinovich4Miasnikov Clinical Cardiology Institute, Moscow, RussiaDepartment of Psychiatry and Psychososmatics, Sechenov University, Moscow, RussiaResearch Institute of Psychiatry, Branch of the Serbsky State Scientific Center for Social and Forensic Psychiatry, Moscow, RussiaFSBSI Mental Health Research Center, Moscow, RussiaDepartment of Radiation Diagnosis and Therapy, Sechenov University, Moscow, Russia Objective: The present study is devoted to the study of brain activation using fMRI in patients with depression (after acute coronary syndrome and somatically healthy) and in healthy volunteers. Method: The study enrolled a total of 51 patients: 11 with depression after acute coronary syndrome, 16 with primary depressive episode and recurrent depression without prior coronary event, and 24 with ACS without depression. The groups were matched by sex and age. The emotional information processing was evaluated with the Pennsylvania Test of Emotion Recognition. All patients underwent fMRI at the time of this test. The data processing was performed with SPM12 and xjView applications. Results: During the processing of emotional information in the depressed patients after ACS, specific activation zones in the frontal cortex (P < 0.001), right fusiform gyrus (P < 0.001), and right insular lobe were identified (P = 0.017). In the patients with primary depressive episode and recurrent depression without ACS, certain zones of activation were identified in frontal cortex (P < 0.001; 0.001), left fusiform gyrus (P < 0.001), occipital cortex (P < 0.001). In the patients who had ACS, without depression, some zones of activation were specified in the right middle occipital gyrus (P < 0.001), the right superior frontal gyrus (P = 0.088), and the putamen projection on the right (P < 0.001) and on the left (P = 0.009), as well as the left insular lobe (P = 0.015). Conclusion: The pathogenesis of depression is significantly associated with the peculiarities of processing emotionally significant information, regardless of the conditions under which it develops. https://ijps.tums.ac.ir/index.php/ijps/article/view/3624Acute Coronary SyndromeDepressionfMRIBrainNeurophysiology |
| spellingShingle | Alena Beliaevskaia Petelin Dmitry Sergeevich Akhapkin Roman Vitalievich Volel Beatrice Albertovna Ternovoy Sergey Konstantinovich Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers Iranian Journal of Psychiatry Acute Coronary Syndrome Depression fMRI Brain Neurophysiology |
| title | Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers |
| title_full | Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers |
| title_fullStr | Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers |
| title_full_unstemmed | Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers |
| title_short | Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers |
| title_sort | comparison of brain activation according to fmri data in patient with depression after acute coronary syndrome and somatically healthy and healthy volunteers |
| topic | Acute Coronary Syndrome Depression fMRI Brain Neurophysiology |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/3624 |
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