Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions
Background: the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. Methods: plasma phytosterol and cytokine concentrations, fatty acid composit...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/12/1699 |
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| author | Sylwia Osowska Marek Kunecki Jacek Sobocki Joanna Tokarczyk Krystyna Majewska Magdalena Burkacka Marek Radkowski Magdalena Makarewicz-Wujec Helena L. Fisk Sultan Mashnafi Sabine Baumgartner Jogchum Plat Philip C. Calder |
| author_facet | Sylwia Osowska Marek Kunecki Jacek Sobocki Joanna Tokarczyk Krystyna Majewska Magdalena Burkacka Marek Radkowski Magdalena Makarewicz-Wujec Helena L. Fisk Sultan Mashnafi Sabine Baumgartner Jogchum Plat Philip C. Calder |
| author_sort | Sylwia Osowska |
| collection | DOAJ |
| description | Background: the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. Methods: plasma phytosterol and cytokine concentrations, fatty acid composition, liver function markers, and triglycerides were measured in 58 adult HPN patients receiving one of three different LEs (soybean oil-based: Intralipid; olive oil-based: ClinOleic; containing fish oil: SMOFLipid). Results: patients receiving Intralipid had higher plasma campesterol and stigmasterol concentrations than those receiving ClinOleic or SMOFLipid. Plasma sterol concentrations were not different between patients receiving ClinOleic and SMOFLipid. Differences in plasma fatty acids reflected the fatty acid composition of the LEs. Markers of liver function did not differ among the three groups. Blood triglycerides were higher with ClinOleic than with Intralipid or SMOFLipid. Total bilirubin correlated positively with the plasma concentrations of two of the phytosterols, ALT correlated positively with one, AST with one, and GGT with three. Conclusions: liver function markers correlate with plasma plant sterol concentrations in adult HPN patients. Adult HPN patients receiving SMOFLipid are more likely to have liver function markers and triglycerides within the normal range than those receiving ClinOleic or Intralipid. The omega-3 fatty acids in SMOFLipid may act to mitigate the adverse effects of plant sterols on liver function. |
| first_indexed | 2024-03-09T17:19:24Z |
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| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T17:19:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a7d8bf12174f46f78f84b48453cac4ac2023-11-24T13:21:51ZengMDPI AGBiology2079-77372022-11-011112169910.3390/biology11121699Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid EmulsionsSylwia Osowska0Marek Kunecki1Jacek Sobocki2Joanna Tokarczyk3Krystyna Majewska4Magdalena Burkacka5Marek Radkowski6Magdalena Makarewicz-Wujec7Helena L. Fisk8Sultan Mashnafi9Sabine Baumgartner10Jogchum Plat11Philip C. Calder12Applied Pharmacy Department, Warsaw Medical University, 02-097 Warsaw, PolandCentre of Clinical Nutrition, Pirogow Hospital, 90-531 Lodz, PolandDepartment of General Surgery and Clinical Nutrition, Centre for Postgraduate Medical Education, 00-416 Warsaw, PolandCentre of Clinical Nutrition, Pirogow Hospital, 90-531 Lodz, PolandDepartment of General Surgery and Clinical Nutrition, Centre for Postgraduate Medical Education, 00-416 Warsaw, PolandCentre of Clinical Nutrition, Pirogow Hospital, 90-531 Lodz, PolandDepartment of Immunopathology, Warsaw Medical University, 02-097 Warsaw, PolandInstitute of Pharmaceutical Care, University of Economics and Human Sciences, 01-043 Warsaw, PolandSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKDepartment of Nutrition and Movement Sciences, NUTRIM School of Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The NetherlandsDepartment of Nutrition and Movement Sciences, NUTRIM School of Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The NetherlandsDepartment of Nutrition and Movement Sciences, NUTRIM School of Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The NetherlandsSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKBackground: the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. Methods: plasma phytosterol and cytokine concentrations, fatty acid composition, liver function markers, and triglycerides were measured in 58 adult HPN patients receiving one of three different LEs (soybean oil-based: Intralipid; olive oil-based: ClinOleic; containing fish oil: SMOFLipid). Results: patients receiving Intralipid had higher plasma campesterol and stigmasterol concentrations than those receiving ClinOleic or SMOFLipid. Plasma sterol concentrations were not different between patients receiving ClinOleic and SMOFLipid. Differences in plasma fatty acids reflected the fatty acid composition of the LEs. Markers of liver function did not differ among the three groups. Blood triglycerides were higher with ClinOleic than with Intralipid or SMOFLipid. Total bilirubin correlated positively with the plasma concentrations of two of the phytosterols, ALT correlated positively with one, AST with one, and GGT with three. Conclusions: liver function markers correlate with plasma plant sterol concentrations in adult HPN patients. Adult HPN patients receiving SMOFLipid are more likely to have liver function markers and triglycerides within the normal range than those receiving ClinOleic or Intralipid. The omega-3 fatty acids in SMOFLipid may act to mitigate the adverse effects of plant sterols on liver function.https://www.mdpi.com/2079-7737/11/12/1699lipid emulsionfish oilphytosterolparenteral nutritionliverinflammation |
| spellingShingle | Sylwia Osowska Marek Kunecki Jacek Sobocki Joanna Tokarczyk Krystyna Majewska Magdalena Burkacka Marek Radkowski Magdalena Makarewicz-Wujec Helena L. Fisk Sultan Mashnafi Sabine Baumgartner Jogchum Plat Philip C. Calder Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions Biology lipid emulsion fish oil phytosterol parenteral nutrition liver inflammation |
| title | Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions |
| title_full | Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions |
| title_fullStr | Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions |
| title_full_unstemmed | Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions |
| title_short | Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions |
| title_sort | potential for omega 3 fatty acids to protect against the adverse effect of phytosterols comparing laboratory outcomes in adult patients on home parenteral nutrition including different lipid emulsions |
| topic | lipid emulsion fish oil phytosterol parenteral nutrition liver inflammation |
| url | https://www.mdpi.com/2079-7737/11/12/1699 |
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