Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice

Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice

We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct a...

Full description

Bibliographic Details
Main Authors:	Nobuaki Egashira, Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara
Format:	Article
Language:	English
Published:	Elsevier 2007-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319342082

Similar Items

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions
by: Nobuaki Egashira, et al.
Published: (2009-01-01)

Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex
by: Nobuaki Egashira, et al.
Published: (2011-01-01)

2,5-Dimethoxy-4-iodoamphetamine (DOI) Inhibits ∆9-Tetrahydrocannabinol-Induced Catalepsy-Like Immobilization in Mice
by: Nobuaki Egashira, et al.
Published: (2007-01-01)

Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
by: Fengling Pu, et al.
Published: (2009-01-01)

N-Acetyl-l-Cysteine Inhibits Marble-Burying Behavior in Mice
by: Nobuaki Egashira, et al.
Published: (2012-01-01)

Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
by: Fengling Pu, et al.
Published: (2007-01-01)

Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion
by: Izzettin Hatip-Al-Khatib, et al.
Published: (2007-01-01)

Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats
by: Katsunori Iwasaki, et al.
Published: (2003-01-01)

Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice
by: Nobuaki Egashira, et al.
Published: (2008-01-01)

Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats
by: Takuya Watanabe, et al.
Published: (2008-01-01)

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
by: Michihiro Fujiwara, et al.
Published: (2010-07-01)

Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder
by: Michihiko Matsushita, et al.
Published: (2005-01-01)

Neuroprotective effect of baicalin on focal cerebral ischemia in rats
by: Jiong Dai, et al.
Published: (2018-01-01)

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test
by: Izzettin Hatip-Al-Khatib, et al.
Published: (2004-01-01)

Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats
by: Adem Bozkurt Aras, et al.
Published: (2015-01-01)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
by: Nagel, S, et al.
Published: (2011)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats
by: Nagel, S, et al.
Published: (2011)

Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice
by: Qiusheng Zheng, et al.
Published: (2012-08-01)

Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia
by: Diana Amantea, et al.
Published: (2019-11-01)

New Perspectives in the Studies on Endocannabinoid and Cannabis: Abnormal Behaviors Associate With CB1 Cannabinoid Receptor and Development of Therapeutic Application
by: Michihiro Fujiwara, et al.
Published: (2004-01-01)

Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review
by: Yazdan Naderi, et al.
Published: (2020-01-01)

Neuroprotective Mechanisms of Calycosin Against Focal Cerebral Ischemia and Reperfusion Injury in Rats
by: Yong Wang, et al.
Published: (2018-01-01)

Neuroprotective effects of curdione against focal cerebral ischemia reperfusion injury in rats
by: Li XJ, et al.
Published: (2017-06-01)

Neuroprotective effect of the RNS60 in a mouse model of transient focal cerebral ischemia
by: Gloria Patricia Baena-Caldas, et al.
Published: (2024-01-01)

GABAA signaling, focal epileptiform synchronization and epileptogenesis
by: Massimo Avoli, et al.
Published: (2022-10-01)

Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation.
by: Arjun Sapkota, et al.
Published: (2017-01-01)

Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
by: Mark B. Plotnikov, et al.
Published: (2023-07-01)

Inhibition of Autophagy Contributes to Melatonin-Mediated Neuroprotection Against Transient Focal Cerebral Ischemia in Rats
by: Yongqiu Zheng, et al.
Published: (2014-01-01)

Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
by: Li Gao, et al.
Published: (2012-01-01)

Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: a neuroimaging and neurotrophin study.
by: Nai-Fang Chi, et al.
Published: (2014-01-01)

Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.
by: Sei Higuchi, et al.
Published: (2012-01-01)

Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats
by: Nobuaki Egashira, et al.
Published: (2018-03-01)

Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia.
by: Bhakta Prasad Gaire, et al.
Published: (2015-01-01)

Electroacupuncture-induced neuroprotection against focal cerebral ischemia in the rat is mediated by adenosine A1 receptors
by: Qin-xue Dai, et al.
Published: (2017-01-01)

Neuroprotective Effect of Smilacis chinae Rhizome on NMDA-Induced Neurotoxicity In Vitro and Focal Cerebral Ischemia In Vivo
by: Ju Yeon Ban, et al.
Published: (2008-01-01)

Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats
by: Syed Suhail Andrabi, et al.
Published: (2017-06-01)

Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia
by: Kotaro Takasaki, et al.
Published: (2011-01-01)

Isotachophoretic determination of theanine
by: Kvasnička Frantšek, et al.
Published: (2006-06-01)

Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents.
by: Pallab Bhattacharya, et al.
Published: (2013-01-01)

Neuroprotective Effect of Activated Protein C on Blood–Brain Barrier Injury During Focal Cerebral Ischemia/Reperfusion
by: Jinqiao Wang, et al.
Published: (2020-05-01)