Current status and future challenges of CAR-T cell therapy for osteosarcoma

Current status and future challenges of CAR-T cell therapy for osteosarcoma

Osteosarcoma, the most common bone malignancy in children and adolescents, poses considerable challenges in terms of prognosis, especially for patients with metastatic or recurrent disease. While surgical intervention and adjuvant chemotherapy have improved survival rates, limitations such as imprac...

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Bibliographic Details
Main Authors: Shizhe Li, He Zhang, Guanning Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
CAR-T
osteosarcoma
immunotherapy
targeted therapy
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1290762/full

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