Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin
Oral drug delivery remains the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. One approach to overcome the solubility and stability limitations is the use of amorphous polymeric prodrug formulations...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/6/337 |
| _version_ | 1827660305519345664 |
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| author | Vinod S. Patil Benjamin C. Burdette J. Zach Hilt Douglass S. Kalika Thomas D. Dziubla |
| author_facet | Vinod S. Patil Benjamin C. Burdette J. Zach Hilt Douglass S. Kalika Thomas D. Dziubla |
| author_sort | Vinod S. Patil |
| collection | DOAJ |
| description | Oral drug delivery remains the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. One approach to overcome the solubility and stability limitations is the use of amorphous polymeric prodrug formulations, such as poly(β-amino ester) (PBAE). PBAE hydrogels, which are biodegradable and pH responsive, have shown promising results for the controlled release of drugs by improving the stability and increasing the solubility of these drugs. In this work, we have evaluated the potential use of PBAE prodrugs in an oral tablet formulation, studying their sustained drug release potential and storage stability. Curcumin, a low solubility, low stability antioxidant drug was used as a model compound. Poly(curcumin β-amino ester) (PCBAE), a crosslinked amorphous network, was synthesized by a previously published method using a commercial diacrylate and a primary diamine, in combination with acrylate-functionalized curcumin. PCBAE-based tablets were made and exhibited a sustained release for 16 h, following the hydrolytic degradation of PCBAE particles into native curcumin. In addition to the release studies, preliminary storage stability was assessed using standard and accelerated stability conditions. As PCBAE degradation is hydrolysis driven, tablet stability was found to be sensitive to moisture. |
| first_indexed | 2024-03-09T23:45:00Z |
| format | Article |
| id | doaj.art-a7dc78796fe54569b4bf2934405e5973 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T23:45:00Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-a7dc78796fe54569b4bf2934405e59732023-11-23T16:45:12ZengMDPI AGGels2310-28612022-05-018633710.3390/gels8060337Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of CurcuminVinod S. Patil0Benjamin C. Burdette1J. Zach Hilt2Douglass S. Kalika3Thomas D. Dziubla4Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USADepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USADepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USADepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USADepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USAOral drug delivery remains the most common and well tolerated method for drug administration. However, its applicability is often limited due to low drug solubility and stability. One approach to overcome the solubility and stability limitations is the use of amorphous polymeric prodrug formulations, such as poly(β-amino ester) (PBAE). PBAE hydrogels, which are biodegradable and pH responsive, have shown promising results for the controlled release of drugs by improving the stability and increasing the solubility of these drugs. In this work, we have evaluated the potential use of PBAE prodrugs in an oral tablet formulation, studying their sustained drug release potential and storage stability. Curcumin, a low solubility, low stability antioxidant drug was used as a model compound. Poly(curcumin β-amino ester) (PCBAE), a crosslinked amorphous network, was synthesized by a previously published method using a commercial diacrylate and a primary diamine, in combination with acrylate-functionalized curcumin. PCBAE-based tablets were made and exhibited a sustained release for 16 h, following the hydrolytic degradation of PCBAE particles into native curcumin. In addition to the release studies, preliminary storage stability was assessed using standard and accelerated stability conditions. As PCBAE degradation is hydrolysis driven, tablet stability was found to be sensitive to moisture.https://www.mdpi.com/2310-2861/8/6/337Poy(β-amino ester)curcuminhydrogelstabletssolubilityamorphous |
| spellingShingle | Vinod S. Patil Benjamin C. Burdette J. Zach Hilt Douglass S. Kalika Thomas D. Dziubla Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin Gels Poy(β-amino ester) curcumin hydrogels tablets solubility amorphous |
| title | Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin |
| title_full | Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin |
| title_fullStr | Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin |
| title_full_unstemmed | Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin |
| title_short | Poly(curcumin β-amino ester)-Based Tablet Formulation for a Sustained Release of Curcumin |
| title_sort | poly curcumin β amino ester based tablet formulation for a sustained release of curcumin |
| topic | Poy(β-amino ester) curcumin hydrogels tablets solubility amorphous |
| url | https://www.mdpi.com/2310-2861/8/6/337 |
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