ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction

ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction

DJ-1 is a redox-sensitive chaperone with reported antioxidant and anti-inflammatory properties in the kidney. The 20 amino acid (aa) peptide ND-13 consists of 13 highly conserved aas from the DJ-1 sequence and a TAT-derived 7 aa sequence that helps in cell penetration. This study aimed to determine...

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Bibliographic Details
Main Authors: Carmen De Miguel, Abigayle C. Kraus, Mitchell A. Saludes, Prasad Konkalmatt, Almudena Ruiz Domínguez, Laureano D. Asico, Patricia S. Latham, Daniel Offen, Pedro A. Jose, Santiago Cuevas
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
renal disease
DJ-1
ND-13
renal inflammation
oxidative stress
UUO
Online Access:https://www.mdpi.com/1422-0067/21/19/7048

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