A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis
Background: Despite the increasing developments in treatment of skin diseases, leishmaniasis is still considered as one of the major health problems. Despite the spontaneously improving of the disease, its scars can highly create emotional and social problems for the patients. In this study, the eff...
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| Format: | Article |
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Isfahan University of Medical Sciences
2017-04-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/7554 |
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| author | Mohammad Ali Nilforoushzadeh Frida Ghazanfarpour Fatemeh Sokhanvari Nazli Ansari Asieh Heidari Mehrdad Maham |
| author_facet | Mohammad Ali Nilforoushzadeh Frida Ghazanfarpour Fatemeh Sokhanvari Nazli Ansari Asieh Heidari Mehrdad Maham |
| author_sort | Mohammad Ali Nilforoushzadeh |
| collection | DOAJ |
| description | Background: Despite the increasing developments in treatment of skin diseases, leishmaniasis is still considered as one of the major health problems. Despite the spontaneously improving of the disease, its scars can highly create emotional and social problems for the patients. In this study, the effect of combination therapy of intralesional glucantime plus glycolic acid 70% and salicylic 20% was compared with intralesional glucantime alone in reducing scars of this disease.
Methods: 75 patients with cutaneous leishmaniasis, which had 2 lesions at the same anatomical location, participated in the study (150 lesions). 75 lesions were treated with combination therapy and 75 with intralesional glucantime alone. For each patient a questionnaire was filled. All the data were analyzed using SPSS software.
Findings: After 8 weeks of treatment, 37.3% of lesions cured completely with intralesional glucantime and 42.7% with combination therapy. There was no statistically significant difference between the improvements among the two groups (P > 0.05).
Conclusion: Intralesional glucantime plus glycolic acid 70% and salicylic 20% was not more effective in cutaneous leishmaniasis compared to intralesional glucantime alone and did not reduce the mean time of improvement. |
| first_indexed | 2024-03-12T10:12:59Z |
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| id | doaj.art-a7ded52cbfbc42139ed9fba0a98446b4 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T10:12:59Z |
| publishDate | 2017-04-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-a7ded52cbfbc42139ed9fba0a98446b42023-09-02T10:43:56ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-04-0134416169316982436A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous LeishmaniasisMohammad Ali Nilforoushzadeh0Frida Ghazanfarpour1Fatemeh Sokhanvari2Nazli Ansari3Asieh Heidari4Mehrdad Maham5Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IranGeneral Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Despite the increasing developments in treatment of skin diseases, leishmaniasis is still considered as one of the major health problems. Despite the spontaneously improving of the disease, its scars can highly create emotional and social problems for the patients. In this study, the effect of combination therapy of intralesional glucantime plus glycolic acid 70% and salicylic 20% was compared with intralesional glucantime alone in reducing scars of this disease. Methods: 75 patients with cutaneous leishmaniasis, which had 2 lesions at the same anatomical location, participated in the study (150 lesions). 75 lesions were treated with combination therapy and 75 with intralesional glucantime alone. For each patient a questionnaire was filled. All the data were analyzed using SPSS software. Findings: After 8 weeks of treatment, 37.3% of lesions cured completely with intralesional glucantime and 42.7% with combination therapy. There was no statistically significant difference between the improvements among the two groups (P > 0.05). Conclusion: Intralesional glucantime plus glycolic acid 70% and salicylic 20% was not more effective in cutaneous leishmaniasis compared to intralesional glucantime alone and did not reduce the mean time of improvement.http://jims.mui.ac.ir/index.php/jims/article/view/7554Cutaneous leishmaniasisGlucantimGlycolic acid 70%Salicylic acid 20% |
| spellingShingle | Mohammad Ali Nilforoushzadeh Frida Ghazanfarpour Fatemeh Sokhanvari Nazli Ansari Asieh Heidari Mehrdad Maham A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis مجله دانشکده پزشکی اصفهان Cutaneous leishmaniasis Glucantim Glycolic acid 70% Salicylic acid 20% |
| title | A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis |
| title_full | A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis |
| title_fullStr | A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis |
| title_full_unstemmed | A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis |
| title_short | A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% with Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis |
| title_sort | comparison of the effects of topical injection of glucantime plus glycolic acid 70 and salicylic acid 20 with topical injection of glucantime alone in the treatment of acute cutaneous leishmaniasis |
| topic | Cutaneous leishmaniasis Glucantim Glycolic acid 70% Salicylic acid 20% |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/7554 |
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