Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3325203?pdf=render |
| _version_ | 1818259492749443072 |
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| author | Matthew C Keller Matthew A Simonson Stephan Ripke Ben M Neale Pablo V Gejman Daniel P Howrigan Sang Hong Lee Todd Lencz Douglas F Levinson Patrick F Sullivan Schizophrenia Psychiatric Genome-Wide Association Study Consortium |
| author_facet | Matthew C Keller Matthew A Simonson Stephan Ripke Ben M Neale Pablo V Gejman Daniel P Howrigan Sang Hong Lee Todd Lencz Douglas F Levinson Patrick F Sullivan Schizophrenia Psychiatric Genome-Wide Association Study Consortium |
| author_sort | Matthew C Keller |
| collection | DOAJ |
| description | Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by ~17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time. |
| first_indexed | 2024-12-12T18:16:18Z |
| format | Article |
| id | doaj.art-a7e013cfd9e84f3f981b739994d0ac22 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-12T18:16:18Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-a7e013cfd9e84f3f981b739994d0ac222022-12-22T00:16:16ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042012-01-0184e100265610.1371/journal.pgen.1002656Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.Matthew C KellerMatthew A SimonsonStephan RipkeBen M NealePablo V GejmanDaniel P HowriganSang Hong LeeTodd LenczDouglas F LevinsonPatrick F SullivanSchizophrenia Psychiatric Genome-Wide Association Study ConsortiumAutozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by ~17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.http://europepmc.org/articles/PMC3325203?pdf=render |
| spellingShingle | Matthew C Keller Matthew A Simonson Stephan Ripke Ben M Neale Pablo V Gejman Daniel P Howrigan Sang Hong Lee Todd Lencz Douglas F Levinson Patrick F Sullivan Schizophrenia Psychiatric Genome-Wide Association Study Consortium Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genetics |
| title | Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. |
| title_full | Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. |
| title_fullStr | Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. |
| title_full_unstemmed | Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. |
| title_short | Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. |
| title_sort | runs of homozygosity implicate autozygosity as a schizophrenia risk factor |
| url | http://europepmc.org/articles/PMC3325203?pdf=render |
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